Musher D M, Saenz C, Griffith D P
Antimicrob Agents Chemother. 1974 Feb;5(2):106-10. doi: 10.1128/AAC.5.2.106.
Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.
乙酰氧肟酸（AHA）是一种有效的脲酶抑制剂，在由产脲酶细菌引起的感染情况下，可防止大鼠尿液碱化和结石形成。由于已描述了AHA的抗菌作用以及卡那霉素与AHA之间的协同作用，我们研究了AHA与12种抗生素对14种革兰氏阴性菌的相互作用。在17%的相互作用中发现了协同作用，有时程度显著；然而，在5%的相互作用中检测到了拮抗作用。在预测AHA和抗生素的抗菌效果之前，需要对感染的生物体进行单独研究。
