无毛小鼠的单纯疱疹病毒皮肤感染：抗病毒化合物治疗
Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds.
作者信息
Klein R J, Friedman-Kien A E, Brady E
出版信息
Antimicrob Agents Chemother. 1974 Mar;5(3):318-22. doi: 10.1128/AAC.5.3.318.
Abstract
A hairless mouse-herpes simplex virus skin infection experimental model was used to evaluate the efficacy of the antiviral compounds 9-beta-d-arabinofuranosyladenine (ara-A), 5-iodo-2'-deoxyuridine (IUdR), and 6-azauridine (aza-U). Ara-A and IUdR, when administered intraperitoneally by several different dosage schedules, reduced the severity of cutaneous herpetic lesions and the incidence of paralysis and increased significantly the number of survivors. A more rapid healing of the lesions and an increase in the mean survival time also was observed. A delay of 24 to 48 h in the initiation of treatment after the infection was more effective than treatments started at the time of inoculation. Treatment with ara-A was somewhat superior to that with IUdR, but aza-U was totally ineffective. Enhancement of the evolution of the infection was noted after treatment with aza-U.
摘要
使用无毛小鼠 - 单纯疱疹病毒皮肤感染实验模型来评估抗病毒化合物9-β-D-阿拉伯呋喃糖基腺嘌呤（阿糖腺苷，ara-A）、5-碘-2'-脱氧尿苷（碘苷，IUdR）和6-氮杂尿苷（氮杂尿苷，aza-U）的疗效。当通过几种不同的给药方案腹腔注射阿糖腺苷和碘苷时，可减轻皮肤疱疹病变的严重程度和麻痹的发生率，并显著增加存活小鼠的数量。还观察到病变愈合加快以及平均存活时间延长。感染后延迟24至48小时开始治疗比接种时开始治疗更有效。阿糖腺苷治疗在某种程度上优于碘苷治疗，但氮杂尿苷完全无效。用氮杂尿苷治疗后发现感染进展加快。
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IDU therapy of herpes simplex.单纯疱疹的注射吸毒疗法。 （不过从医学常理看，这个表述不太符合常见医学内容，可能原文有误，正常应该是关于单纯疱疹的某种规范治疗方法表述，比如“Intermittent dosing therapy of herpes simplex”之类，单纯“IDU therapy”这样表述容易误解，这里是按照字面翻译）
Arch Ophthalmol. 1962 May;67:583-91. doi: 10.1001/archopht.1962.00960020583012.
2
Kethoxal for treatment of cutaneous herpes simplex.用于治疗皮肤单纯疱疹的乙二醛。
Proc Soc Exp Biol Med. 1968 Oct;129(1):235-9. doi: 10.3181/00379727-129-33294.
3
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4
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J Invest Dermatol. 1973 Apr;60(4):203-6. doi: 10.1111/1523-1747.ep12724476.
5
Experimental zoster-like herpes simplex in hairless mice.无毛小鼠中的实验性带状疱疹样单纯疱疹
J Invest Dermatol. 1971 Mar;56(3):193-9. doi: 10.1111/1523-1747.ep12260802.
6
[Experimental herpes simplex virus infection of the skin of hairless mice].[无毛小鼠皮肤的实验性单纯疱疹病毒感染]
Arch Klin Exp Dermatol. 1970;239(1):22-9.
7
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