Klein R J, Friedman-Kien A E
Antimicrob Agents Chemother. 1985 May;27(5):763-8. doi: 10.1128/AAC.27.5.763.
The effect of topical and systemic treatment with 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the evolution of herpes simplex virus-induced skin infection in hairless mice was investigated. Systemic (subcutaneous) treatment with a 10-mg/kg dose and topical applications with a 5% cream started up to 48 h after infection prevented the development of severe skin lesions and a fatal outcome. However, the establishment of latent infections was prevented only by topical treatment started at 6 h after infection. Systemic (50 mg/kg) and topical treatments started 48 h after infection reduced virus titers in the skin and ganglia and promoted rapid clearance of virus from these sites. The clearance of infectious virus from ganglia during the acute phase of infection was followed by early establishment of latency. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (0.03 microgram/ml) significantly inhibited the synthesis of infectious virus in explant cultures of latently infected ganglia, and at concentrations higher than 8 micrograms/ml no infectious virus was detectable in ganglia explant cultures.
研究了9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤局部和全身治疗对无毛小鼠单纯疱疹病毒诱导的皮肤感染演变的影响。感染后48小时内开始的10毫克/千克剂量的全身（皮下）治疗和5%乳膏的局部应用可预防严重皮肤病变的发展和致命结局。然而，仅在感染后6小时开始的局部治疗可预防潜伏感染的建立。感染后48小时开始的全身（50毫克/千克）和局部治疗可降低皮肤和神经节中的病毒滴度，并促进病毒从这些部位的快速清除。感染急性期神经节中传染性病毒的清除之后是潜伏期的早期建立。9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤（0.03微克/毫升）显著抑制潜伏感染神经节外植体培养物中传染性病毒的合成，浓度高于8微克/毫升时，神经节外植体培养物中未检测到传染性病毒。
