不同抗疱疹药物对无胸腺裸鼠皮肤单纯疱疹病毒感染进行局部治疗时的相对效价。
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.
作者信息
Descamps J, De Clercq E, Barr P J, Jones A S, Walker R T, Torrence P F, Shugar D
出版信息
Antimicrob Agents Chemother. 1979 Nov;16(5):680-2. doi: 10.1128/AAC.16.5.680.
Abstract
Thirteen established anti-herpes compounds have been directly compared in a single assay system for their effects on the development of herpetic skin lesions, and mortality associated therewith, in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus type 1 (KOS). When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.
摘要
在一个单一的检测系统中，对13种已有的抗疱疹化合物在接种1型单纯疱疹病毒（KOS）的无胸腺裸鼠（nu/nu）中对疱疹性皮肤损伤的发展及其相关死亡率的影响进行了直接比较。当局部应用（在水溶性软膏中以1%的浓度）时，膦甲酸、E-5-（2-溴乙烯基）-2'-脱氧尿苷、阿昔洛韦和膦甲酸钠成为最有效的药物。
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本文引用的文献
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Suppression of herpes simplex virus infection by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒感染的抑制作用。
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Comparison of the therapeutic effects of five antiviral agents on cutaneous herpesvirus infection in guinea pigs.五种抗病毒药物对豚鼠皮肤疱疹病毒感染治疗效果的比较。
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5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.5-丙基-2'-脱氧尿苷：一种特异性抗疱疹剂。
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(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷：一种高效且选择性的抗疱疹药物。
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947-51. doi: 10.1073/pnas.76.6.2947.
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Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.膦甲酸钠三钠对豚鼠皮肤疱疹病毒感染的治疗作用。
Antimicrob Agents Chemother. 1978 Sep;14(3):408-13. doi: 10.1128/AAC.14.3.408.
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Trisodium phosphonoformate, a new antiviral compound.膦甲酸钠三钠，一种新型抗病毒化合物。
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9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.9-（2-羟乙氧甲基）鸟嘌呤对疱疹病毒组病毒的活性。
Nature. 1978 Apr 13;272(5654):583-5. doi: 10.1038/272583a0.
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5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.5-羟基-2'-脱氧尿苷的5-O-烷基化衍生物作为潜在的抗病毒剂。5-丙炔氧基-2'-脱氧尿苷的抗疱疹活性。
J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018.
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