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相似文献

1
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.不同抗疱疹药物对无胸腺裸鼠皮肤单纯疱疹病毒感染进行局部治疗时的相对效价。
Antimicrob Agents Chemother. 1979 Nov;16(5):680-2. doi: 10.1128/AAC.16.5.680.
2
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对无毛小鼠皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1984 Aug;26(2):155-9. doi: 10.1128/AAC.26.2.155.
3
Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.膦甲酸处理无毛小鼠单纯疱疹病毒诱导的皮肤感染对感觉神经节潜伏感染的影响。
Antimicrob Agents Chemother. 1979 Sep;16(3):266-70. doi: 10.1128/AAC.16.3.266.
4
E-5-(2-bromovinyl)-2'-deoxyuridine vs. interferon in the systemic treatment of infection with herpes simplex virus of athymic nude mice.E-5-(2-溴乙烯基)-2'-脱氧尿苷与干扰素对无胸腺裸鼠单纯疱疹病毒感染的全身治疗比较
J Infect Dis. 1981 Jun;143(6):846-52. doi: 10.1093/infdis/143.6.846.
5
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.（S）-1-（3-羟基-2-膦酰甲氧基丙基）胞嘧啶在小鼠单纯疱疹病毒感染多种模型中的疗效。
Antimicrob Agents Chemother. 1991 Apr;35(4):701-6. doi: 10.1128/AAC.35.4.701.
6
Cutaneous herpes simplex virus infections.皮肤单纯疱疹病毒感染
Am Fam Physician. 1991 May;43(5):1655-64.
7
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.腺嘌呤的膦酰基甲氧基烷基衍生物在体内实验性单纯疱疹病毒和痘苗病毒感染中的疗效。
Antimicrob Agents Chemother. 1989 Feb;33(2):185-91. doi: 10.1128/AAC.33.2.185.
8
Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds.无毛小鼠的单纯疱疹病毒皮肤感染：抗病毒化合物治疗
Antimicrob Agents Chemother. 1974 Mar;5(3):318-22. doi: 10.1128/AAC.5.3.318.
9
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗小鼠实验性单纯疱疹病毒性脑炎。
Antimicrob Agents Chemother. 1982 Sep;22(3):421-5. doi: 10.1128/AAC.22.3.421.
10
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷：一种高效且选择性的抗疱疹药物。
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947-51. doi: 10.1073/pnas.76.6.2947.

引用本文的文献

1
Efficacies of topical formulations of foscarnet and acyclovir and of 5-percent acyclovir ointment (Zovirax) in a murine model of cutaneous herpes simplex virus type 1 infection.膦甲酸钠和阿昔洛韦局部制剂以及5%阿昔洛韦软膏（阿昔洛韦）在1型皮肤单纯疱疹病毒感染小鼠模型中的疗效。
Antimicrob Agents Chemother. 2000 Jan;44(1):30-8. doi: 10.1128/AAC.44.1.30-38.2000.
2
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗实验性单纯疱疹性角膜炎
Antimicrob Agents Chemother. 1980 Jan;17(1):8-12. doi: 10.1128/AAC.17.1.8.
3
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗小鼠实验性单纯疱疹病毒性脑炎。
Antimicrob Agents Chemother. 1982 Sep;22(3):421-5. doi: 10.1128/AAC.22.3.421.
4
Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection.阿昔洛韦在不同载体中对豚鼠皮肤的渗透及其与实验性皮肤单纯疱疹病毒感染局部治疗疗效的相关性
Antimicrob Agents Chemother. 1984 Jan;25(1):10-5. doi: 10.1128/AAC.25.1.10.
5
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对无毛小鼠皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1984 Aug;26(2):155-9. doi: 10.1128/AAC.26.2.155.
6
Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.阿昔洛韦。对其药效学特性及治疗效果的综述。
Drugs. 1983 Nov;26(5):378-438. doi: 10.2165/00003495-198326050-00002.
7
Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs.局部应用5-乙基-2'-脱氧尿苷与阿昔洛韦治疗豚鼠皮肤单纯疱疹病毒感染的比较。
Antimicrob Agents Chemother. 1985 Jul;28(1):103-6. doi: 10.1128/AAC.28.1.103.
8
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.E-5-(2-[¹³¹I]碘乙烯基)-2'-脱氧尿苷在犬体内的药代动力学和代谢
Antimicrob Agents Chemother. 1986 Feb;29(2):320-4. doi: 10.1128/AAC.29.2.320.
9
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.1-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖基)-5-碘胞嘧啶及其代谢产物在细胞培养物中和在脑内感染单纯疱疹病毒2型的小鼠中对1型和2型单纯疱疹病毒的活性。
Antimicrob Agents Chemother. 1986 Jan;29(1):77-84. doi: 10.1128/AAC.29.1.77.
10
Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.阿昔洛韦。对其抗病毒活性、药代动力学特性及治疗效果的最新综述。
Drugs. 1989 Mar;37(3):233-309. doi: 10.2165/00003495-198937030-00002.

本文引用的文献

1
Suppression of herpes simplex virus infection by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒感染的抑制作用。
Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.
2
Comparison of the therapeutic effects of five antiviral agents on cutaneous herpesvirus infection in guinea pigs.五种抗病毒药物对豚鼠皮肤疱疹病毒感染治疗效果的比较。
Arch Virol. 1978;58(4):277-88. doi: 10.1007/BF01317820.
3
5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.5-丙基-2'-脱氧尿苷：一种特异性抗疱疹剂。
Antimicrob Agents Chemother. 1978 Mar;13(3):545-7. doi: 10.1128/AAC.13.3.545.
4
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷：一种高效且选择性的抗疱疹药物。
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947-51. doi: 10.1073/pnas.76.6.2947.
5
Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.膦甲酸钠三钠对豚鼠皮肤疱疹病毒感染的治疗作用。
Antimicrob Agents Chemother. 1978 Sep;14(3):408-13. doi: 10.1128/AAC.14.3.408.
6
Trisodium phosphonoformate, a new antiviral compound.膦甲酸钠三钠，一种新型抗病毒化合物。
Science. 1978 Sep 1;201(4358):819-21. doi: 10.1126/science.210500.
7
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.9-（2-羟乙氧甲基）鸟嘌呤对疱疹病毒组病毒的活性。
Nature. 1978 Apr 13;272(5654):583-5. doi: 10.1038/272583a0.
8
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.5-羟基-2'-脱氧尿苷的5-O-烷基化衍生物作为潜在的抗病毒剂。5-丙炔氧基-2'-脱氧尿苷的抗疱疹活性。
J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018.

不同抗疱疹药物对无胸腺裸鼠皮肤单纯疱疹病毒感染进行局部治疗时的相对效价。

Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

作者信息

Descamps J, De Clercq E, Barr P J, Jones A S, Walker R T, Torrence P F, Shugar D

出版信息

Antimicrob Agents Chemother. 1979 Nov;16(5):680-2. doi: 10.1128/AAC.16.5.680.

DOI:10.1128/AAC.16.5.680
PMID:526011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352929/
Abstract

Thirteen established anti-herpes compounds have been directly compared in a single assay system for their effects on the development of herpetic skin lesions, and mortality associated therewith, in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus type 1 (KOS). When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.

摘要

在一个单一的检测系统中，对13种已有的抗疱疹化合物在接种1型单纯疱疹病毒（KOS）的无胸腺裸鼠（nu/nu）中对疱疹性皮肤损伤的发展及其相关死亡率的影响进行了直接比较。当局部应用（在水溶性软膏中以1%的浓度）时，膦甲酸、E-5-（2-溴乙烯基）-2'-脱氧尿苷、阿昔洛韦和膦甲酸钠成为最有效的药物。