Herrmann J, Schaps D, Rusche H J, Berger M, Krüskemper H L, von zur Hühlen A, Hackenberg K, Reinwein D
Clin Endocrinol (Oxf). 1975 Mar;4(2):205-12. doi: 10.1111/j.1365-2265.1975.tb01528.x.
In 189 of 334 patients, who had been treated with fractionated doses of radioiodine for Graves' disease 7-15 years ago, the serum concentrations of triiodothyronine have been estimated in additition to the following parameters: Protein bound 127-iodine (PB-127-I), free thyroxine index, cholesterol- and TSH-level in serum, tendon reflex time and clinical index according to Billewitz et al. (1969). In forty-one of the 189 sera the free T4 (AFT4) and free T3 (AFT3) concentrations were measured as well. The following hormonal and clinical patterns were observed: (1) Euthyroidism, with all parameters within the normal range in 148 patients (equals 78-4%). (2) Hypothyroidism with low serum T3, PBI, AFT4, AFT3 and elevated TSH six subjects (equals 3-2%). (3) Persistent hyperthyroidism with increased thyroid hormone concentrations and low TSH in seven cases (equals 3-7%). (4) In twenty-eight clinically euthyroid patients (equals 14-8%) TSH was elevated with normal PBI and AFT4. Twenty of these subjects had a low normal T3 and in nine the T3 was clearly in the hypothyroid range (40 plus or minus 12 mug/dl). (5) The constellation of normal T3, low T4 and elevated TSH, which has been frequently found after radioiodine therapy, has been seen in only moderate form in ten cases.
在334例患者中，有189例于7至15年前接受过分次剂量放射性碘治疗Graves病，除下列参数外，还测定了血清三碘甲状腺原氨酸浓度：蛋白结合127碘（PB - 127 - I）、游离甲状腺素指数、血清胆固醇和促甲状腺激素水平、腱反射时间以及根据Billewitz等人（1969年）制定的临床指数。在这189份血清中，有41份还测定了游离T4（AFT4）和游离T3（AFT3）浓度。观察到以下激素和临床模式：（1）甲状腺功能正常，148例患者所有参数均在正常范围内（占78.4%）。（2）甲状腺功能减退，6例患者血清T3、PBI、AFT4、AFT3降低，促甲状腺激素升高（占3.2%）。（3）7例患者持续甲状腺功能亢进，甲状腺激素浓度升高，促甲状腺激素降低（占3.7%）。（4）28例临床甲状腺功能正常的患者（占14.8%）促甲状腺激素升高，PBI和AFT4正常。其中20例患者T3略低于正常，9例患者T3明显处于甲状腺功能减退范围（40±12μg/dl）。（5）放射性碘治疗后常见的T3正常、T4降低和促甲状腺激素升高的组合，仅在10例患者中呈中度表现。
