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一种由寄生曲霉突变体合成的红色色素,可能是黄曲霉毒素生物合成途径中的一种新中间体。

A red pigment synthesized by an Aspergillus parasiticus mutant as a possible new intermediate in the aflatoxin biosynthetic pathway.

作者信息

García M E, Herce M D, Blanco J L, Suárez G

机构信息

Departamento Patología Animal I, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.

出版信息

J Appl Bacteriol. 1994 Nov;77(5):553-9. doi: 10.1111/j.1365-2672.1994.tb04401.x.

Abstract

The isolation of a red pigment from an Aspergillus parasiticus mutant obtained by 366 nm u.v. light treatment of A. parasiticus NRRL 2999 is described. Studies of conversion in aflatoxin B1 and G1 suggest that the red pigment could be a possible new intermediate in the aflatoxin biosynthetic pathway not described to date, and this has been verified by studies in gas chromatography/mass spectrometry. The solubility and stability characteristics under refrigeration storage, and the influence of the temperature and the pH on its production by the A. parasiticus mutant were also studied. It grew best at 30 degrees C and pH 6. The red pigment was most soluble in ethyl acetate. The results obtained in water are emphasized where there was high stability.

摘要

描述了从寄生曲霉NRRL 2999经366 nm紫外线处理获得的寄生曲霉突变体中分离出一种红色色素。黄曲霉毒素B1和G1转化的研究表明,该红色色素可能是黄曲霉毒素生物合成途径中迄今未描述的一种新的中间体,这已通过气相色谱/质谱研究得到验证。还研究了该红色色素在冷藏储存下的溶解性和稳定性特征,以及温度和pH对寄生曲霉突变体产生该色素的影响。它在30℃和pH 6时生长最佳。该红色色素在乙酸乙酯中溶解度最大。强调了在水中获得的具有高稳定性的结果。

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