夫西地酸钠对厌氧菌的体外活性。
In vitro activity of sodium fusidate against anaerobic bacteria.
作者信息
Steinkraus G E, McCarthy L R
出版信息
Antimicrob Agents Chemother. 1979 Aug;16(2):120-2. doi: 10.1128/AAC.16.2.120.
The microtiter broth dilution method was employed to determine the in vitro susceptibility of 525 recent clinical isolates of anaerobic bacteria to sodium fusidate. The minimal inhibitory concentrations of sodium fusidate ranged from </=0.06 to 1.0 mug/ml for 155 strains of anaerobic gram-positive rods and 130 strains of anaerobic gram-positive cocci. Minimal inhibitory concentrations ranging from </=0.06 to 32 mug/ml were observed for 240 strains of anaerobic gram-negative rods. Among the latter group a minimal inhibitory concentration of 16 mug/ml or greater was encountered with 16% of 45 Bacteroides fragilis strains, 19% of 32 Bacteroides thetaiotaomicron, and all 7 strains of Fusobacterium necrophorum. Minimal inhibitory concentrations for Veillonella parvula, the only gram-negative coccus tested, ranged from 0.5 to 8.0 mug/ml.
采用微量肉汤稀释法测定了525株近期临床分离的厌氧菌对夫西地酸钠的体外敏感性。155株厌氧革兰氏阳性杆菌和130株厌氧革兰氏阳性球菌的夫西地酸钠最低抑菌浓度范围为≤0.06至1.0μg/ml。240株厌氧革兰氏阴性杆菌的最低抑菌浓度范围为≤0.06至32μg/ml。在后一组中，45株脆弱拟杆菌中有16%、32株多形拟杆菌中有19%以及所有7株坏死梭杆菌的最低抑菌浓度为16μg/ml或更高。所测试的唯一革兰氏阴性球菌——小韦荣球菌的最低抑菌浓度范围为0.5至8.0μg/ml。
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