羟羧氧酰胺菌素（LY127935）与头孢噻肟对厌氧菌作用的比较。
Comparison of moxalactam (LY127935) and cefotaxime against anaerobic bacteria.
作者信息
Jorgensen J H, Crawford S A, Alexander G A
出版信息
Antimicrob Agents Chemother. 1980 May;17(5):901-4. doi: 10.1128/AAC.17.5.901.
Abstract
The in vitro activities of moxalactam (LY127935 [6059S]) and cefotaxime were compared with those of cefoxitin, cefamandole, cefuroxime, carbenicillin, and penicillin by agar dilution susceptibility testing of a variety of anaerobic bacteria. Moxalactam proved to be the most active agent tested against Bacteroides fragilis and other species of the B. fragilis group. Moxalactam and cefotaxime showed activity similar to the other drugs against the remaining species of Bacteroides, Fusobacterium, Actinomyces, Propionibacterium, and Veillonella. Penicillin was the most effective drug tested against most species of Clostridium, the anaerobic gram-positive cocci, and Eubacterium lentum.
摘要
通过对多种厌氧菌进行琼脂稀释药敏试验，比较了拉氧头孢（LY127935 [6059S]）和头孢噻肟与头孢西丁、头孢孟多、头孢呋辛、羧苄西林及青霉素的体外活性。结果表明，拉氧头孢是针对脆弱拟杆菌及脆弱拟杆菌群其他菌种检测的最具活性的药物。拉氧头孢和头孢噻肟对其余拟杆菌属、梭杆菌属、放线菌属、丙酸杆菌属及韦荣球菌属菌种的活性与其他药物相似。青霉素是针对大多数梭菌属菌种、厌氧革兰氏阳性球菌及迟缓真杆菌检测的最有效药物。
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