Cochrane G M, Prieto F, Hickey B, Benatar S R, Clark T J
Thorax. 1974 Jul;29(4):389-93. doi: 10.1136/thx.29.4.389.
, , 389-393. Three simple tests, maximum expiratory flow volume curve, maximum expiratory volume time curve and closing volume', were used to detect early airways obstruction in 21 smokers. A high proportion had abnormal values for MEF, MEF, and FET (86%, 71%, and 62% respectively) with a relatively normal FEV. There was a good correlation between tests of small airways obstruction obtained from the forced expiratory manoeuvre. The measurement of closing volume' (phase 4/VC%) was less satisfactory as there were difficulties with interpretation of the records in half of the studies. We conclude that the forced expiratory manoeuvre can be used to detect early airways obstruction as well as providing FEV and vital capacity. The importance of early diagnosis of airways obstruction is not yet clear and further information is required about its natural history, and its relation to smoking habits and to the more advanced and less reversible stages of airways obstruction. It may be possible to use early detection to prevent the development of disabling chronic obstructive bronchitis.
389 - 393。采用三项简单测试，即最大呼气流量容积曲线、最大呼气量时间曲线和“闭合容积”，对21名吸烟者进行早期气道阻塞检测。很大一部分人在最大呼气流量（MEF）、最大呼气中期流量（MMEF）和用力呼气时间（FET）方面值异常（分别为86%、71%和62%），而第一秒用力呼气容积（FEV）相对正常。从用力呼气动作获得的小气道阻塞测试之间存在良好相关性。“闭合容积”（第4相/肺活量百分比）的测量不太令人满意，因为在一半的研究中记录解读存在困难。我们得出结论，用力呼气动作可用于检测早期气道阻塞，同时提供FEV和肺活量。气道阻塞早期诊断的重要性尚不清楚，需要进一步了解其自然病史，以及它与吸烟习惯以及气道阻塞更严重和更不易逆转阶段的关系。利用早期检测预防致残性慢性阻塞性支气管炎的发展或许是可行的。
