Mok J Y, Waugh P R, Simpson H
Arch Dis Child. 1979 Jul;54(7):506-11. doi: 10.1136/adc.54.7.506.
Fifty children with a previous history of Mycoplasma pneumoniae respiratory tract infection were assessed clinically, and pulmonary function tests carried out after an interval ranging from 1 1/2 to 9 1/2 years (median 2 1/2). 23 suffered from recurrent wheezy bronchitis or asthma, and in 5 the index illness appeared to precipitate the wheezing tendency. All were symptom-free when respiratory function tests were performed. Simple tests of ventilatory function (PEFR, FEV, and FVC) were within normal limits. Increased bronchial reactivity after exercise (a fall in PEFR greater than 15% resting value) was demonstrated only in children known to have asthma. Maximum expiratory flow rates in air at 50% of vital capacity (V mas50) were within the normal range in all patients with the exception of two. The response in flow rate at 50% of vital capacity after inalation of an 80% helium and 20% oxygen mixture delta V max50) was reduced (P less than 0.001) in asymptomatic patients with a history of M. pneumoniae respiratory infection, when compared with normal data from 48 healthy schoolchildren without a background of significant respiratory illnesses. These findings indicate impairment of small airways function, even in totally symptom-free children in the study group.
对50名曾有过肺炎支原体呼吸道感染病史的儿童进行了临床评估，并在间隔1.5至9.5年（中位数为2.5年）后进行了肺功能测试。23名儿童患有复发性喘息性支气管炎或哮喘，其中5名儿童的此次疾病似乎引发了喘息倾向。在进行呼吸功能测试时，所有儿童均无症状。通气功能的简单测试（呼气峰值流速、第一秒用力呼气容积和用力肺活量）均在正常范围内。仅在已知患有哮喘的儿童中显示出运动后支气管反应性增加（呼气峰值流速下降超过静息值的15%）。除两名患者外，所有患者在肺活量50%时的最大呼气流量率（V mas50）均在正常范围内。与48名无明显呼吸道疾病背景的健康学童的正常数据相比，有肺炎支原体呼吸道感染病史的无症状患者在吸入80%氦气和20%氧气混合物后肺活量50%时的流速反应（δV max50）降低（P<0.001）。这些发现表明，即使在研究组中完全无症状的儿童中，小气道功能也存在损害。
