Sabato A R, Martin A J, Marmion B P, Kok T W, Cooper D M
Arch Dis Child. 1984 Nov;59(11):1034-7. doi: 10.1136/adc.59.11.1034.
One hundred and eight children presenting with Mycoplasma pneumoniae infection were assessed during the acute illness and followed for three years. The incidence of wheezing with the acute infection (40%) was greater than expected in a normal childhood population. The initial illness precipitated wheezing for the first time in some subjects but others wheezed only with the acute illness. In non-asthmatic subjects significant bronchodilator responsiveness was present one month after infection. Children given erythromycin during the first seven days of their illness had a significantly shorter fever duration compared with those treated inappropriately. No significant effects of treatment were noted on pulmonary function three years later but non-asthmatic children had abnormal mean forced expiratory volume in one second and forced expiratory flow after 50% of the expired vital capacity compared with 64 healthy controls. These findings indicate impaired function three years after initial infection.
对108名患有肺炎支原体感染的儿童在急性期进行评估，并随访三年。急性感染时喘息的发生率（40%）高于正常儿童人群的预期。最初的疾病在一些受试者中首次引发喘息，但其他受试者仅在急性疾病时喘息。在非哮喘受试者中，感染后一个月出现显著的支气管扩张剂反应性。与治疗不当的儿童相比，在患病的前七天接受红霉素治疗的儿童发热持续时间明显缩短。三年后，治疗对肺功能无显著影响，但与64名健康对照相比，非哮喘儿童的一秒用力呼气量和呼气肺活量的50%后的用力呼气流量均值异常。这些发现表明初次感染三年后功能受损。
