Silk D B, Webb J P, Lane A E, Clark M L, Dawson A M
Gut. 1974 Jun;15(6):444-9. doi: 10.1136/gut.15.6.444.
The characteristics of glucose, glycine, L-alanine, and glycyl-L-alanine absorption from the jejunum and ileum have been compared in normal human subjects. A perfusion technique has been used, and correct positioning of the perfusion tube has been confirmed by measuring the differential jejunal and ileal handling of bicarbonate. Glucose and glycine were absorbed faster from the jejunum than from the ileum of all subjects studied, and L-alanine was absorbed faster from the jejunum than from the ileum in five out of six subjects studied. In contrast, the dipeptide glycyl-L-alanine was absorbed at comparable rates from the jejunum and ileum. Higher concentrations of free amino acids were detected in the luminal contents aspirated during the ileal dipeptide perfusions.These results emphasize the importance of oligopeptide transport in the absorption of protein digestion products, especially in the human ileum, and the practical implications of these findings are discussed.
在正常人类受试者中，已对空肠和回肠对葡萄糖、甘氨酸、L-丙氨酸和甘氨酰-L-丙氨酸的吸收特性进行了比较。采用了灌注技术，并通过测量空肠和回肠对碳酸氢盐的不同处理情况来确认灌注管的正确定位。在所有研究对象中，葡萄糖和甘氨酸从空肠的吸收速度比从回肠快，在六名研究对象中的五名中，L-丙氨酸从空肠的吸收速度比从回肠快。相比之下，二肽甘氨酰-L-丙氨酸从空肠和回肠的吸收速度相当。在回肠二肽灌注期间吸出的腔内内容物中检测到较高浓度的游离氨基酸。这些结果强调了寡肽转运在蛋白质消化产物吸收中的重要性，尤其是在人类回肠中，并讨论了这些发现的实际意义。
