Silk D B, Kumar P J, Webb J P, Lane A E, Clark M L, Dawson A M
Gut. 1975 Apr;16(4):261-7. doi: 10.1136/gut.16.4.261.
A double-lumen perfusion technique has been used to investigate jejunal and ileal absorption of glucose, water, and electrolytes in a group of patients with untreated adult coeliac disease. Correct positioning of the tube was confirmed by measuring the differential jejunal and ileal handling of bicarbonate. Eight control subjects and eight patients with coeliac disease were perfused with an isotonic electrolyte solution containing 50 mM glucose and 25 mM bicarbonate. The group of coeliac patients had impaired jejunal absorption of glucose (P less than 0.001), water (P less than 0.01), sodium (P less than 0.02), and chloride (P greater than 0.05) compared with the control group. In contrast the group of coeliac patients had normal ileal glucose and water absorption and increased ileal sodium (P greater than 0.01) and chloride (P greater than 0.05) absorption compared with the controls. Evidence for ileal adaptation was found in three individual patients who had absorptive values outside 2SD of the normal mean. The results indicate that the distal small intestine in coeliac disease has the ability to adopt to the damage and loss of absorptive capacity in the proximal small intestine.
采用双腔灌注技术，对一组未经治疗的成人乳糜泻患者空肠和回肠对葡萄糖、水及电解质的吸收情况进行了研究。通过测量空肠和回肠对碳酸氢盐的不同处理情况，确认了导管的正确位置。给8名对照受试者和8名乳糜泻患者灌注含50 mM葡萄糖和25 mM碳酸氢盐的等渗电解质溶液。与对照组相比，乳糜泻患者组空肠对葡萄糖（P<0.001）、水（P<0.01）、钠（P<0.02）的吸收受损，对氯的吸收（P>0.05）无明显差异。相比之下，与对照组相比，乳糜泻患者组回肠对葡萄糖和水的吸收正常，回肠对钠（P>0.01）和氯（P>0.05）的吸收增加。在3名单个患者中发现了回肠适应性的证据，其吸收值超出正常均值的2个标准差。结果表明，乳糜泻患者远端小肠有能力适应近端小肠吸收能力的损害和丧失。
