Katz D H, Strechschulte D J, Benacerraf B
J Allergy Clin Immunol. 1975 Jun;55(6):403-10. doi: 10.1016/0091-6749(75)90079-2.
Immunological tolerance has been induced in 2,4-dinitrophenyl (DNP)-specific bone marrow-derived or B lymphocytes of the IgE AND IgG antibody classes by treatment of rats with the DNP derivative of D-amino acid copolymer, D-glutamic acid, D-lysine (D-GL). The tolerant state is manifested as an inability of treated rats to produce serum anti-DNP antibodies and the failure of peritoneal cells from tolerant animals to release histamine following in vitro antigen challenge. The implications of these and related observations for potential therapeutic measures in clinical hypersensitivity states are discussed.
通过用D-氨基酸共聚物、D-谷氨酸、D-赖氨酸（D-GL）的2,4-二硝基苯基（DNP）衍生物处理大鼠，已在IgE和IgG抗体类别的DNP特异性骨髓来源或B淋巴细胞中诱导了免疫耐受。耐受状态表现为经处理的大鼠无法产生血清抗DNP抗体，以及耐受动物的腹腔细胞在体外抗原攻击后无法释放组胺。讨论了这些及相关观察结果对临床超敏反应状态潜在治疗措施的意义。
