苯妥英在体外对甲状旁腺激素诱导的骨吸收的抑制作用。
Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
作者信息
Harris M, Jenkins M V, Wills M R
出版信息
Br J Pharmacol. 1974 Mar;50(3):405-8. doi: 10.1111/j.1476-5381.1974.tb09616.x.
Abstract
1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.
摘要
本文报道了苯妥英钠和苯巴比妥对甲状旁腺激素体外诱导骨钙动员作用的研究。
在治疗浓度（15微克/毫升）下，苯妥英钠显著抑制甲状旁腺激素诱导的骨钙释放。
苯妥英钠对骨钙动员的抑制作用可能在长期接受抗惊厥药物治疗的癫痫患者低钙血症的维持中起作用。
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Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.苯妥英在体外对甲状旁腺激素诱导的骨吸收的抑制作用。
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本文引用的文献
1
The effect of ascorbic acid on the growth of chick bone rudiments in chemically defined medium.抗坏血酸对化学限定培养基中鸡胚骨原基生长的影响。
Exp Cell Res. 1966 Apr;42(1):178-88. doi: 10.1016/0014-4827(66)90330-2.
2
Influence of sodium on calcium transport by the rat small intestine.钠对大鼠小肠钙转运的影响。
Am J Physiol. 1969 Jun;216(6):1351-9. doi: 10.1152/ajplegacy.1969.216.6.1351.
3
Disturbance of calcium metabolism by anticonvulsant drugs.抗惊厥药物对钙代谢的干扰。
Br Med J. 1970 Oct 10;4(5727):73-6. doi: 10.1136/bmj.4.5727.73.
4
A sensitive in vitro method for studying the induction and inhibition of bone resorption.一种用于研究骨吸收诱导和抑制的灵敏体外方法。
Calcif Tissue Res. 1970;4(4):339-49. doi: 10.1007/BF02279136.
5
Studies on the metabolism of phenytoin.苯妥英钠代谢的研究。
Epilepsia. 1966 Sep;7(3):238-45. doi: 10.1111/j.1528-1157.1966.tb03802.x.
6
Osteomalacia with long-term anticonvulsant therapy in epilepsy.癫痫患者长期抗惊厥治疗导致的骨软化症。
Br Med J. 1970 Oct 10;4(5727):69-72. doi: 10.1136/bmj.4.5727.69.
7
Altered calcium metabolism in epileptic children on anticonvulsants.接受抗惊厥药物治疗的癫痫儿童的钙代谢改变。
Br Med J. 1971 Oct 23;4(5781):202-4. doi: 10.1136/bmj.4.5781.202.
8
Latent osteomalacia in epileptic patients on anticonvulsants.服用抗惊厥药的癫痫患者中的潜在骨软化症。
Br Med J. 1972 Sep 23;3(5829):738-9. doi: 10.1136/bmj.3.5829.738.
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Anticonvulsant hypocalcaemia.抗惊厥药所致低钙血症
Br Med J. 1972 Jun 24;2(5816):768-9. doi: 10.1136/bmj.2.5816.768-c.
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[Osteomalacia due to a long-term antiepileptic treatment].长期抗癫痫治疗导致的骨软化症
Schweiz Med Wochenschr. 1972 Sep 23;102(38):1333-8.
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