Kattamis C, Syriopoulou V, Davri-Karamouzi Y, Demetriou D, Matsaniotis N
Arch Dis Child. 1974 Jun;49(6):450-3. doi: 10.1136/adc.49.6.450.
The prevalence of Australia-antigen and -antibody was studied in 196 patients with thalassaemia, aged 10 months to 14 years. Au-Ag was detected in 14 patients (7%) and Au-Ab in 63 (32%). The prevalence of Au-Ag was in inverse relation to the age of the patients and in direct relation to the number of units of transfused blood. By contrast, the prevalence of Au-Ab was directly related to both the age and the number of transfused blood units. Au-Ab was detected in 61% of patients who had received more than 60 units of blood, but in only 11% of patients who had received less than 20 units. No sex difference was found in the prevalence of Au-Ag and Au-Ab. Only 2 patients with Au-Ag were without clinical or biochemical evidence of hepatitis; in all the remaining 12 patients Au-Ag persisted throughout the period of observation of from 5 to 18 months. During the same period Au-Ab was found to persist in all patients in whom it was detected. The persistence of Au-Ag and the synthesis of Au-Ab appear to be related to (a) repeated infection with type B virus and (b) the host's immune response.
对196例年龄在10个月至14岁的地中海贫血患者进行了澳大利亚抗原和抗体的患病率研究。14例患者（7%）检测到澳大利亚抗原（Au-Ag），63例（32%）检测到澳大利亚抗体（Au-Ab）。Au-Ag的患病率与患者年龄呈负相关，与输血单位数呈正相关。相比之下，Au-Ab的患病率与年龄和输血单位数均呈正相关。在接受超过60个单位血液的患者中，61%检测到Au-Ab，但在接受少于20个单位血液的患者中，仅11%检测到。未发现Au-Ag和Au-Ab的患病率存在性别差异。仅2例Au-Ag患者无肝炎的临床或生化证据；其余12例患者在5至18个月的观察期内Au-Ag持续存在。在同一时期，发现所有检测到Au-Ab的患者中该抗体均持续存在。Au-Ag的持续存在和Au-Ab的合成似乎与（a）B型病毒的反复感染和（b）宿主的免疫反应有关。
