Van Den Brenk H A, Kelly H, Orton C
Br J Cancer. 1974 May;29(5):365-72. doi: 10.1038/bjc.1974.84.
Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduced the effect of local irradiation of lung tissues in increasing tumour colony efficiency (CFE) in the lungs; it also tended to reduce similar effects of sublethal whole body irradiation. A non-steroidal anti-inflammatory drug, phenylbutazone, also reduced CFE in locally irradiated lungs in the rat.The results obtained indicate that corticosteroids do not stimulate the growth of implanted tumour cells by suppressing host immunity but decrease their clonogenic growth by inhibiting local inflammatory reactions to cell arrest, and similarly to local tissue damage caused by x-irradiation; it is asserted that such inflammatory reactions are growth promoting and thereby stimulate regeneration of stroma (repair) and also support survival and early growth of the tumour cell.
在给大鼠静脉注射同种异体肿瘤细胞之前，给予高剂量的抗炎皮质类固醇，可使肺和肾中细胞的“着床”及克隆生长减少5至10倍，并降低移植到腿部肌肉中的细胞的生长和扩散。类固醇疗法还降低了肺部组织局部照射对提高肺部肿瘤集落效率（CFE）的作用；它也倾向于降低亚致死性全身照射的类似作用。一种非甾体抗炎药保泰松，也降低了大鼠局部照射肺部的CFE。所得结果表明，皮质类固醇并非通过抑制宿主免疫来刺激植入肿瘤细胞的生长，而是通过抑制对细胞停滞的局部炎症反应以及与X射线照射引起的局部组织损伤类似的反应，来降低其克隆生长；有人认为，这种炎症反应具有促进生长的作用，从而刺激基质再生（修复），并支持肿瘤细胞的存活和早期生长。
