Tucker E M, Moor R M, Rowson L E
Immunology. 1974 Mar;26(3):613-21.
The blood groups are described of three sheep chimaeras produced by injection of blastomere cells into fertilized eggs of different parental origin. Evidence is presented that these chimaeras had a blood type which could only have been derived from both sets of parental genes. Two antigenically distinct red cell populations were identified in all three sheep and chimaerism of serum transferrin and albumin types was also present in two of them. One sheep had a mixture of red cell potassium types and another of haemoglobin types. Soluble R and O blood group substances were present together in the saliva of all three sheep and on the red cells of two of them. The relative proportions of the two red cell populations changed with age of the sheep, the blastomere-derived population becoming less. In one sheep one transferrin type also declined. A fourth sheep studied was not a blood chimaera but was apparently composed of blood derived entirely from that of the transplanted blastomere cells. All four sheep were phenotypically male but studies of cultured leucocytes showed that female cells were present in two of the chimaeras (34 per cent and 89 per cent respectively).
描述了通过将卵裂球细胞注入不同亲本来源的受精卵而产生的三只绵羊嵌合体的血型。有证据表明，这些嵌合体具有一种只能来自两组亲本基因的血型。在所有三只绵羊中都鉴定出了两种抗原性不同的红细胞群体，并且在其中两只绵羊中还存在血清转铁蛋白和白蛋白类型的嵌合现象。一只绵羊具有红细胞钾类型的混合物，另一只具有血红蛋白类型的混合物。所有三只绵羊的唾液中都同时存在可溶性R和O血型物质，其中两只绵羊的红细胞上也有。两种红细胞群体的相对比例随绵羊年龄而变化，卵裂球来源的群体比例逐渐减少。在一只绵羊中，一种转铁蛋白类型也有所下降。研究的第四只绵羊不是血液嵌合体，显然是由完全来自移植的卵裂球细胞的血液组成。所有四只绵羊在表型上都是雄性，但对培养的白细胞的研究表明，在两只嵌合体中存在雌性细胞（分别为34%和89%）。
