Mascetti Victoria L, Pedersen Roger A
British Heart Foundation Oxbridge Centre for Regenerative Medicine, University of Cambridge, Cambridge, CB2 0SZ, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0SZ, UK.
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0SZ, UK; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0SZ, UK.
Cell Stem Cell. 2016 Aug 4;19(2):163-175. doi: 10.1016/j.stem.2016.07.018.
Chimeras are widely acknowledged as the gold standard for assessing stem cell pluripotency, based on their capacity to test donor cell lineage potential in the context of an organized, normally developing tissue. Experimental chimeras provide key insights into mammalian developmental mechanisms and offer a resource for interrogating the fate potential of various pluripotent stem cell states. We highlight the applications and current limitations presented by intra- and inter-species chimeras and consider their future contribution to the stem cell field. Despite the technical and ethical demands of experimental chimeras, including human-interspecies chimeras, they are a provocative resource for achieving regenerative medicine goals.
嵌合体被广泛认为是评估干细胞多能性的金标准，这是基于它们在有组织的、正常发育的组织环境中测试供体细胞谱系潜能的能力。实验性嵌合体为深入了解哺乳动物发育机制提供了关键见解，并为探究各种多能干细胞状态的命运潜能提供了一种资源。我们强调了种内和种间嵌合体的应用及当前局限性，并探讨了它们未来对干细胞领域的贡献。尽管实验性嵌合体，包括人类种间嵌合体，存在技术和伦理要求，但它们是实现再生医学目标的一种具有启发性的资源。
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