Ravitch M M, Brolin R E
Ann Surg. 1979 Sep;190(3):382-391. doi: 10.1097/00000658-197909000-00014.
In the performance of end-to-end jejunoileal shunt, operative mortality can be nearly eliminated and late deaths largely prevented by assiduous care and follow-up. We attempted to prevent serious complications by regular outpatient visits. However, 703 outpatient visits costing $49.00 per visit failed to improve results. There were 170 readmissions among 64 patients lasting 4--57 days (average hospital stay--16 days per admission at $3,000.00). Twenty-four of those patients alive and followed 18 months or more (53%) sustained adequate weight loss and were free of major problems. Patient satisfaction nevertheless appears high, and when there has been a good weight loss, even severe problems tend to be glossed over by the patient. The ultimate outcome is still unknown, but it seems clear that many of the patients are in a state of controlled malnutrition, which may lead to progressive penalties. We have documented gross pathologic lesions in the bypass enteritis syndrome and draw attention to neurologic sequelae of the bypass, which probably represents deficiency manifestations. Despite brilliant results in some patients and satisfactory results in perhaps half, the cost in life, suffering, dollars, patient and physician time, the uncertain long-term effects, and the unpredictability of the weight loss, all place in question the appropriateness of jejunoileal shunt as the remedy for morbid obesity.
在进行端到端空肠回肠分流术时,通过悉心护理和随访,手术死亡率几乎可以消除,晚期死亡也能在很大程度上得到预防。我们试图通过定期门诊随访来预防严重并发症。然而,703次门诊随访(每次花费49美元)并未改善治疗效果。64例患者中有170次再次入院,持续时间为4至57天(平均每次住院16天,每次花费3000美元)。其中24例存活且随访18个月或更长时间的患者(53%)体重减轻适当,且无重大问题。不过患者满意度似乎较高,而且当体重减轻良好时,即使存在严重问题,患者往往也会忽视。最终结果仍然未知,但很明显许多患者处于营养控制不良的状态,这可能会导致逐渐加重的不良后果。我们已记录了旁路肠炎综合征的大体病理病变,并提请注意旁路的神经后遗症,这可能代表了缺乏症表现。尽管一些患者取得了显著效果,大约一半患者取得了满意效果,但生命、痛苦、金钱、患者和医生时间方面的成本、不确定的长期影响以及体重减轻的不可预测性,都让人质疑空肠回肠分流术作为治疗病态肥胖症疗法的合理性。