Penttila A, Trump B F
Science. 1974 Jul 19;185(4147):277-8. doi: 10.1126/science.185.4147.277.
The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism.
本研究表明，细胞外酸中毒可保护艾氏腹水瘤细胞和大鼠肾皮质细胞免受缺氧损伤。所测量的参数包括细胞钾、三磷酸腺苷以及活体染料摄取量。细胞在pH值为5.6至6.5时比在pH值为7.4时存活时间更长；pH值为7.9时最具损害性。这些发现表明，缺氧细胞产生质子可能是一种保护性反馈机制。
