Linder D P, Poberiĭ I A, Ul'ianov M I, Zubkov B A, Stetsenko O N
Arkh Anat Gistol Embriol. 1979 Jul;77(7):58-65.
Cyto- and histological analysis of the whole immunogenic system at the development of an acute experimental appendicitis in rabbits has demonstrated that all the constituent parts of the system are involved into the reaction. In the central organ of immunity--thymus the main change is its progressive exhaustion, while peripheral organs of immunity are subjected to rather essential cytological rearrangements and activation of both cellular and humoral immunity. Accordingly to the type of the reaction, two groups of peripheral organs of immunity can be distinguish: the first--the appendix and the iliocecal lymph node which predominantly participate in the immunoblastic reaction and in the reaction of young plasmatic cells and demonstrate increased signs of immature cells emigration; the second--the axillary lymph node, as a representative of somatic nodes, and the spleen--the main carriers of the reaction in mature plasmic cells. Structural peculiarities of the complex appendix--iliocecal lymph node in intact animals and in the experiment make it possible to consider the complex as a peculiar functional link of the immune peripheral organs.
对兔急性实验性阑尾炎发病过程中整个免疫原系统的细胞和组织学分析表明，该系统的所有组成部分均参与了反应。在免疫中枢器官——胸腺中，主要变化是其进行性耗竭，而免疫外周器官则经历了相当显著的细胞学重排以及细胞免疫和体液免疫的激活。根据反应类型，可区分出两组免疫外周器官：第一组——阑尾和回盲部淋巴结，它们主要参与免疫母细胞反应以及年轻浆细胞的反应，并表现出未成熟细胞迁移增加的迹象；第二组——作为体淋巴结代表的腋窝淋巴结和脾脏——成熟浆细胞反应的主要载体。完整动物和实验中阑尾——回盲部淋巴结复合体的结构特点使其有可能被视为免疫外周器官的一种特殊功能联系。
