Fleming R W, Williams F D, Wailes K A
J Bacteriol. 1967 Oct;94(4):855-9. doi: 10.1128/jb.94.4.855-859.1967.
The effects of chloramphenicol and p-fluorophenylalanine (p-FPA) on growth, proportion of motile cells, average rate of motility, and the chemotactic response of a methionine auxotroph of Escherichia coli K-12 were studied. Kinetic studies revealed that the inhibition of chemotaxis by p-FPA can be explained by the effect on growth, proportion of motile cells, and average rate of motility rather than a selective inhibition of chemotaxis per se. The effect of chloramphenicol on chemotaxis could not be explained in terms of these characteristics. It is concluded that low concentrations of chloramphenicol, unlike p-FPA, selectively inhibit chemotaxis.
研究了氯霉素和对氟苯丙氨酸（p-FPA）对大肠杆菌K-12蛋氨酸营养缺陷型菌株的生长、运动细胞比例、平均运动速率和趋化反应的影响。动力学研究表明，p-FPA对趋化性的抑制作用可以通过其对生长、运动细胞比例和平均运动速率的影响来解释，而不是对趋化性本身的选择性抑制。氯霉素对趋化性的影响不能用这些特性来解释。得出的结论是，与p-FPA不同，低浓度的氯霉素选择性地抑制趋化性。
