Masters J R, Millis R R, King R J, Rubens R D
Br J Cancer. 1979 May;39(5):536-9. doi: 10.1038/bjc.1979.98.
Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy. In addition, tumours with oestrogen-receptor activity (a feature associated with a high rate of response) but with no elastosis were unlikely to respond, suggesting that a combination of the 2 predictive indices might be more valuable than either taken alone.
对51例晚期乳腺癌患者内分泌治疗的反应与来自其原发性肿瘤组织切片中的弹性组织变性程度进行了比较。弹性组织变性与反应之间似乎存在关联：无弹性组织变性的肿瘤显示出比有明显弹性组织变性的肿瘤更低的反应率，这表明这种简单方法可能为内分泌治疗反应提供有用的预测指标。此外，具有雌激素受体活性（与高反应率相关的特征）但无弹性组织变性的肿瘤不太可能有反应，这表明这两种预测指标结合起来可能比单独使用任何一种更有价值。
