雌激素受体与晚期乳腺癌的内分泌治疗反应
Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.
作者信息
Roberts M M, Rubens R D, King R J, Hawkins R A, Millis R R, Hayward J L, Forrest A P
出版信息
Br J Cancer. 1978 Sep;38(3):431-6. doi: 10.1038/bjc.1978.225.
Abstract
The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.
摘要
在一项合作性前瞻性研究中，对119例患者测定了肿瘤雌激素受体蛋白（ER）含量与内分泌治疗反应之间的关系。80例可检测到ER的患者中，有28例根据国际抗癌联盟（UICC）标准对治疗有反应，相比之下，39例无ER的患者中只有3例有反应。研究发现活检部位不影响结果，但组织样本中的肿瘤含量与受体的存在显著相关。讨论了此类研究的组织问题。
相似文献
1
Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.雌激素受体与晚期乳腺癌的内分泌治疗反应
Br J Cancer. 1978 Sep;38(3):431-6. doi: 10.1038/bjc.1978.225.
2
Estrogen receptors and response to endocrine therapy and cytotoxic chemotherapy in advanced breast cancer.雌激素受体与晚期乳腺癌内分泌治疗及细胞毒性化疗反应
Cancer. 1980 Dec 15;46(12 Suppl):2922-4. doi: 10.1002/1097-0142(19801215)46:12+<2922::aid-cncr2820461435>3.0.co;2-d.
3
Estrophilin assays in breast cancer: quantitative features and application to the mastectomy specimen.乳腺癌中的雌激素受体测定：定量特征及其在乳房切除标本中的应用。
Cancer. 1980 Dec 15;46(12 Suppl):2783-8. doi: 10.1002/1097-0142(19801215)46:12+<2783::aid-cncr2820461408>3.0.co;2-4.
4
Prediction of endocrine response in breast cancer by immunocytochemical detection of oestrogen receptor in fine-needle aspirates.
Lancet. 1987 Sep 26;2(8561):701-3. doi: 10.1016/s0140-6736(87)91071-3.
5
[Present status of endocrine therapy of breast cancer: a surgeon's view].[乳腺癌内分泌治疗的现状：外科医生的观点]
Gan To Kagaku Ryoho. 1984 May;11(5):981-8.
6
[Hormonal therapy of the advanced breast cancer ].[晚期乳腺癌的激素治疗]
Arch Geschwulstforsch. 1982 May;52(3):231-40.
7
8
[Endocrine therapy of breast cancer].[乳腺癌的内分泌治疗]
Sov Med. 1981(12):54-9.
9
Clinical significance of the quantitative assessment of estrogen receptors in advanced breast cancer.晚期乳腺癌中雌激素受体定量评估的临床意义
Cancer. 1980 Dec 15;46(12 Suppl):2889-95. doi: 10.1002/1097-0142(19801215)46:12+<2889::aid-cncr2820461430>3.0.co;2-4.
10
Oestrogen receptors in primary and advanced breast cancer: an eight year review of 704 cases.原发性和晚期乳腺癌中的雌激素受体：704例病例的八年回顾
Br J Cancer. 1987 Jan;55(1):67-73. doi: 10.1038/bjc.1987.14.
引用本文的文献
1
Oestrogen receptor: a stable phenotype in breast cancer.雌激素受体：乳腺癌中的一种稳定表型。
Br J Cancer. 1996 Jan;73(1):5-12. doi: 10.1038/bjc.1996.2.
2
Endogenous peroxidase: an alternative to oestrogen receptor in the management of breast cancer?内源性过氧化物酶：在乳腺癌治疗中可替代雌激素受体？
Br J Cancer. 1980 Apr;41(4):648-51. doi: 10.1038/bjc.1980.111.
3
Oestrogen receptor concentration in primary breast cancer and axillary node metastases.原发性乳腺癌及腋窝淋巴结转移灶中雌激素受体浓度
Breast Cancer Res Treat. 1981;1(3):245-51. doi: 10.1007/BF01806264.
4
Oestrogen-receptor status and sites of metastasis in breast cancer.乳腺癌中的雌激素受体状态与转移部位
Br J Cancer. 1981 Sep;44(3):456-9. doi: 10.1038/bjc.1981.205.
5
Cellularity and the quantitation of estrogen receptors.
Breast Cancer Res Treat. 1982;2(3):239-42. doi: 10.1007/BF01806936.
6
Oestrogen receptors in primary and advanced breast cancer: an eight year review of 704 cases.原发性和晚期乳腺癌中的雌激素受体：704例病例的八年回顾
Br J Cancer. 1987 Jan;55(1):67-73. doi: 10.1038/bjc.1987.14.
7
Oestrogen receptor activity in breast cancer detected at a prevalence screening examination.
Breast Cancer Res Treat. 1987 Dec;10(3):267-72. doi: 10.1007/BF01805763.
8
The relevance of control histology in oestrogen receptor estimation.对照组织学在雌激素受体评估中的相关性。
Br J Cancer. 1987 Nov;56(5):617-8. doi: 10.1038/bjc.1987.252.
9
Epidermal growth factor receptor (EGFr) status associated with failure of primary endocrine therapy in elderly postmenopausal patients with breast cancer.表皮生长因子受体（EGFr）状态与老年绝经后乳腺癌患者一线内分泌治疗失败相关。
Br J Cancer. 1988 Dec;58(6):810-4. doi: 10.1038/bjc.1988.315.
10
Immunocytochemical reactivity of breast cancer tissue with antibodies to neuron-specific enolase and an adenocarcinoma-associated glycolipid antigen.
Virchows Arch A Pathol Anat Histopathol. 1989;415(6):539-44. doi: 10.1007/BF00718647.
本文引用的文献
1
Comparison of soluble oestrogen and progestin receptor content of primary breast tumours from Japan and Britain.
Eur J Cancer (1965). 1977 Sep;13(9):967-70. doi: 10.1016/0014-2964(77)90174-8.
2
Assessment of response to therapy in advanced breast cancer.晚期乳腺癌治疗反应的评估。
Br J Cancer. 1977 Mar;35(3):292-8. doi: 10.1038/bjc.1977.42.
3
Measurement of oestradiol receptors by five institutions on common tissue samples.五个机构对常见组织样本进行雌二醇受体的测量。
Br J Cancer. 1978 Sep;38(3):428-30. doi: 10.1038/bjc.1978.224.
4
A simple method for the determination of oestrogen receptor concentrations in breast tumours and other tissues.一种测定乳腺肿瘤及其他组织中雌激素受体浓度的简单方法。
Clin Chim Acta. 1975 Oct 15;64(2):203-10. doi: 10.1016/0009-8981(75)90202-8.
5
Pathological review of breast lesions analyzed for estrogen receptor protein.对雌激素受体蛋白分析的乳腺病变进行病理检查。
Cancer Res. 1975 Nov;35(11 Pt 1):3187-94.
Zotero 插件