Roberts M M, Rubens R D, King R J, Hawkins R A, Millis R R, Hayward J L, Forrest A P
Br J Cancer. 1978 Sep;38(3):431-6. doi: 10.1038/bjc.1978.225.
The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.
在一项合作性前瞻性研究中，对119例患者测定了肿瘤雌激素受体蛋白（ER）含量与内分泌治疗反应之间的关系。80例可检测到ER的患者中，有28例根据国际抗癌联盟（UICC）标准对治疗有反应，相比之下，39例无ER的患者中只有3例有反应。研究发现活检部位不影响结果，但组织样本中的肿瘤含量与受体的存在显著相关。讨论了此类研究的组织问题。
