在肖普乳头瘤以及Vx7和Vx2癌中检测到一种病毒干扰物质。
The detection of a viral interfering substance in the Shope papilloma and the Vx7 and Vx2 carcinomas.
作者信息
Langston D P, Sobin L H
出版信息
J Exp Med. 1967 Nov 1;126(5):887-97. doi: 10.1084/jem.126.5.887.
Abstract
In vivo assay of Shope papilloma protein extract and in vitro assay of extracts from Shope papilloma, Vx7 and Vx2 carcinomas showed strong interferon-like activity in the papilloma and moderate activity in the carcinomas. The interpretation is that the presence of viral nucleic acid in all three tumors stimulated the production of this substance even though fluorescent antibody studies reveal the protein coat only in the papilloma and Vx7.
摘要
对肖普乳头瘤蛋白提取物进行的体内试验以及对肖普乳头瘤、Vx7和Vx2癌提取物进行的体外试验表明，该乳头瘤具有很强的类干扰素活性，而癌组织具有中等活性。其解释是，尽管荧光抗体研究仅在乳头瘤和Vx7中发现了蛋白衣壳，但这三种肿瘤中病毒核酸的存在都刺激了这种物质的产生。
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本文引用的文献
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A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM.一种可移植的兔癌，来源于病毒诱导的乳头瘤，并以隐蔽或改变形式包含病毒。
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CANCERS DERIVING FROM THE VIRUS PAPILLOMAS OF WILD RABBITS UNDER NATURAL CONDITIONS.在自然条件下从野兔乳头瘤病毒衍生而来的癌症。
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TUMORIGENIC NUCLEIC ACID EXTRACTS FROM TISSUES OF A TRANSPLANTABLE CARCINOMA, VX7.可移植癌VX7组织的致瘤核酸提取物
J Natl Cancer Inst. 1965 Mar;34:431-7.
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THE VIRAL CARRIER STATE IN ANIMAL CELL CULTURES.动物细胞培养中的病毒携带状态
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Studies on vaccinia virus plaque formation and its inhibition by interferon. II. Dynamics of plaque formation by vaccinia virus in the presence of interferon.痘苗病毒蚀斑形成及其受干扰素抑制的研究。II. 干扰素存在下痘苗病毒蚀斑形成的动力学
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Recovery of rubella virus from army recruits.从新兵中分离出风疹病毒。
Proc Soc Exp Biol Med. 1962 Oct;111:225-30. doi: 10.3181/00379727-111-27750.
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Studies on vaccinia virus plaque formation and its inhibition by interferon. III. A simplified plaque inhibition assay of interferon.痘苗病毒蚀斑形成及其受干扰素抑制的研究。III. 一种简化的干扰素蚀斑抑制试验。
Virology. 1963 Mar;19:302-9. doi: 10.1016/0042-6822(63)90068-0.
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J Exp Med. 1957 Oct 1;106(4):555-62. doi: 10.1084/jem.106.4.555.
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