一种可移植的兔癌，来源于病毒诱导的乳头瘤，并以隐蔽或改变形式包含病毒。
A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM.
机构信息
Laboratories of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1940 May 31;71(6):813-38. doi: 10.1084/jem.71.6.813.
Abstract
A squamous cell carcinoma derived from a virus-induced rabbit papilloma has been propagated in fourteen successive groups of animals. It grows rapidly now in most individuals to which it is transplanted, killing early and metastasizing frequently. The original cancer was the outcome of alterations in epidermal cells already rendered neoplastic by the virus, and the latter, or an agent nearly related to it, has persisted and increased in the malignant tissue, as a study of the blood of the first ten groups of cancerous animals has shown. An antibody capable of specifically neutralizing the virus in vitro appeared in the blood of every new host in which the tumor enlarged progressively, and reached a titer comparable with that obtaining in animals which had long carried large papillomas. The antibody was absent from normal rabbits and those in which the cancer failed to grow. The implications of these facts are considered.
摘要
从病毒诱导的兔乳头瘤中衍生的鳞状细胞癌已在十四组连续的动物中繁殖。现在，它在大多数移植到的个体中迅速生长，早期致死并经常转移。最初的癌症是病毒已经使表皮细胞发生癌变的结果，而后者或与其密切相关的一种物质，在恶性组织中持续存在并增加，正如对前十组癌变动物血液的研究所示。一种能够在体外特异性中和病毒的抗体出现在每个新宿主的血液中，肿瘤在这些新宿主中逐渐增大，并且其效价与长期携带大乳头瘤的动物中获得的效价相当。该抗体不存在于正常兔和那些肿瘤未生长的兔中。考虑了这些事实的含义。
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