氨基糖对大肠杆菌中分解代谢物阻遏的影响。
Effect of amino sugars on catabolite repression in Escherichia coli.
作者信息
Dobrogosz W J
出版信息
J Bacteriol. 1968 Feb;95(2):578-84. doi: 10.1128/jb.95.2.578-584.1968.
Abstract
N-acetylglucosamine was found to be a good repressor source for catabolite repression of the beta-galactosidase system in Escherichia coli. It was found capable of increasing the severity of repression by glucose or gluconate when included in the medium with either of these substrates. N-acetylglucosamine was shown to be assimilated under these conditions, but had no effect on culture growth rates. Its influence on catabolite repression was not altered by growth in the presence of inhibiting levels of penicillin. These findings indicated that catabolite repression may be associated with certain reactions of amino sugar metabolism. A working model has been formulated along these lines and will be used to explore this possible relationship further.
摘要
已发现N-乙酰葡糖胺是大肠杆菌中β-半乳糖苷酶系统分解代谢阻遏的良好阻遏物来源。当它与葡萄糖或葡糖酸盐中的任何一种一起包含在培养基中时，能够增强葡萄糖或葡糖酸盐的阻遏作用。在这些条件下，N-乙酰葡糖胺可被同化，但对培养物生长速率没有影响。在存在抑制水平青霉素的情况下生长，其对分解代谢阻遏的影响未改变。这些发现表明，分解代谢阻遏可能与氨基糖代谢的某些反应有关。已沿着这些思路构建了一个工作模型，并将用于进一步探索这种可能的关系。
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