McNally N J, George K C, de Ronde J
Br J Radiol. 1979 Aug;52(620):642-9. doi: 10.1259/0007-1285-52-620-642.
The ability of acutely hypoxic tumour cells to recover from sublethal damage following irradiation in vivo and in vitro has been measured using a single tumour system. The methods of assay were tumour growth delay, local tumour control and tumour cell survival in vitro following treatment in vivo or in vitro. Tumours in vivo or cells in vitro rendered acutely hypoxic during irradiation were irradiated with either single doses or two doses 24 hours apart. Cells left in situ had a greater capacity for recovery than those treated either in vivo or in vitro and then assayed in vitro. It is suggested that tumours may not show a systematically reduced capacity for recovery relative to normal tissues, unless chronically hypoxic tumour cells have a reduced capacity for recovery and determine the response. However, the results imply that deductions as to the ability of tumour cells to recover from sublethal damage (whether chronically hypoxic or not), which rely on in vitro assays, may underestimate the extent of recovery.
利用单一肿瘤系统，已对急性缺氧肿瘤细胞在体内和体外受照射后从亚致死损伤中恢复的能力进行了测定。检测方法包括肿瘤生长延迟、局部肿瘤控制以及体内或体外处理后体外肿瘤细胞的存活情况。在照射期间急性缺氧的体内肿瘤或体外细胞，接受单次剂量或间隔24小时的两次剂量照射。留在原位的细胞比在体内或体外处理后再进行体外检测的细胞具有更强的恢复能力。有人提出，除非慢性缺氧肿瘤细胞的恢复能力降低并决定反应，否则肿瘤相对于正常组织可能不会表现出系统性降低的恢复能力。然而，结果表明，依赖体外检测来推断肿瘤细胞从亚致死损伤中恢复的能力（无论是否为慢性缺氧），可能会低估恢复的程度。
