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正常小鼠以及经历初次或二次免疫反应的小鼠的腹膜巨噬细胞在体内摄取抗原的情况。

Antigen uptake in vivo by peritoneal macrophages from normal mice, and those undergoing primary or secondary responses.

作者信息

Rhodes J M, Lind I

出版信息

Immunology. 1968 Apr;14(4):511-25.

PMID:4871348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409386/
Abstract

The uptake of human serum albumin and ferritin by peritoneal macrophages from normal, primary and secondary response mice has been studied. Both antigens were ingested by the macrophages irrespective of whether they were injected simultaneously or sequentially. Less than 1 per cent of the cells ingested only one antigen. There was no indication that one antigen was ingested in preference to the other in any of the groups of mice. The significance of these findings for the immune response is discussed.

摘要

对来自正常、初次免疫和再次免疫小鼠的腹腔巨噬细胞摄取人血清白蛋白和铁蛋白的情况进行了研究。无论这两种抗原是同时注射还是先后注射，巨噬细胞均会摄取它们。不到1%的细胞只摄取了一种抗原。没有迹象表明在任何一组小鼠中存在优先摄取一种抗原而非另一种抗原的情况。讨论了这些发现对免疫反应的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/058b/1409386/c6ef7899a675/immunology00399-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/058b/1409386/c6ef7899a675/immunology00399-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/058b/1409386/c6ef7899a675/immunology00399-0069-a.jpg

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本文引用的文献

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Antigen elimination from the blood as an early manifestation of the immune response.作为免疫反应早期表现的血液中抗原清除。
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IN VITRO STUDIES ON THE FATE OF ANTIGEN. IV. THE FATE OF SOLUBLE AND PRECIPITATED ANTIGEN-ANTIBODY COMPLEXES IN THE PRESENCE OF GUINEA PIG EXUDATE CELLS, CORRELATED WITH THEIR SKIN REACTIVITY.抗原命运的体外研究。IV. 豚鼠渗出细胞存在时可溶性和沉淀性抗原-抗体复合物的命运，及其与皮肤反应性的相关性。
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Immunology. 1971 May;20(5):839-42.
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Comparison of antigen uptake by peritoneal macrophages and veiled cells from the thoracic duct using isotope-, FITC-, or gold-labelled antigen.使用同位素标记、异硫氰酸荧光素（FITC）标记或金标记抗原，比较腹膜巨噬细胞和胸导管被膜细胞对抗原的摄取情况。
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