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黄曲霉毒素中毒所致肝炎。印度西部的一次疫情。

Hepatitis due to aflatoxicosis. An outbreak in Western India.

作者信息

Krishnamachari K A, Bhat R V, Nagarajan V, Tilak T B

出版信息

Lancet. 1975 May 10;1(7915):1061-3. doi: 10.1016/s0140-6736(75)91829-2.

DOI:10.1016/s0140-6736(75)91829-2
PMID:48730
Abstract

Parts of Western India have experienced an outbreak of hepatitis affecting man and dogs and characterised by jaundice, rapidly developing ascites, portal hypertension, and a high mortality-rate. The disease was associated with the consumption of maize contaminated heavily with Aspergillus flavus. Analysis of contaminated samples showed that affected people could have consumed between 2 and 6 mg. of aflatoxin daily over a period of a month. A specimen of liver obtained at necropsy showed bileduct proliferation and giant cells. The disease appears to be a result of aflatoxicosis.

摘要

印度西部部分地区爆发了一种影响人和狗的肝炎,其特征为黄疸、腹水迅速形成、门静脉高压和高死亡率。该疾病与食用被黄曲霉严重污染的玉米有关。对受污染样本的分析表明,受影响的人在一个月的时间里每天可能摄入了2至6毫克的黄曲霉毒素。尸检时获得的一份肝脏标本显示有胆管增生和巨细胞。这种疾病似乎是黄曲霉毒素中毒的结果。

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