Tandon H D, Tandon B N, Ramalingaswami V
Arch Pathol Lab Med. 1978 Jul;102(7):372-6.
An epidemic of liver disease, characterized by onset with high fever, rapidly progressive jaundice, and ascites occurred in a rural area of India. Several hundred people were affected and mortality was high. The epidemic was heralded by the appearance of similar features in the village dogs. Liver biopsy specimens from eight cases and autopsy material from one human case and two dogs were studied. Characteristic features were centrizonal scarring, hepatic venous occlusion, ductular proliferation and cholestasis, focal syncytial giant-cell tr-nsformation of hepatocytes, and pericellular fibrosis. Toxic quantities of aflatoxin B1 were found in samples of corn, the staple food grain of the people, that was obtained from the domestic food stores. The etiology of the disease could not be unequivocally established, but aflatoxins, perhaps in combination with other factors, may have been the cause.
印度一个农村地区爆发了一种肝病疫情，其特征为起病时伴有高热、迅速进展的黄疸和腹水。数百人受到影响，死亡率很高。此次疫情在村里的狗身上出现类似特征后开始。对8例患者的肝活检标本以及1例人类病例和2只狗的尸检材料进行了研究。特征性表现为中央区瘢痕形成、肝静脉闭塞、小胆管增生和胆汁淤积、肝细胞局灶性合体细胞巨细胞转化以及细胞周围纤维化。在从家庭食品储存处获取的人们的主食谷物玉米样本中发现了有毒量的黄曲霉毒素B1。该疾病的病因尚未明确确定，但黄曲霉毒素可能与其他因素共同作用，也许是病因所在。
