Pokrotniek Iu Ia, Strelis E A, Pominova V B, Sitkin S I, Skuia N A
Ter Arkh. 1986;58(2):45-8.
Histochemical studies with Congo red (to determine the size of an acid forming area) and methylene blue (to detect enterolization foci) were carried out in 46 and 45 patients with chronic ulcer in the stomach body, respectively. Gastrobiopsy specimens from the fundal and pyloric gland portions were subjected to a morphological study. A follow-up over a course of disease showed prognostically unfavorable significance of the acid forming area value exceeding 1/6 of the stomach area, the presence of unchanged gastric mucosa in these portions and the absence of enterolization foci with respect to both cicatrization and frequent recurring of the ulcer crater. The spreading and deepening of gastric changes in the gastric mucosa were regarded as sanogenetic factors in patients with chronic peptic ulcers.