镉，硫蛋白合成中的一种效应物。
Cadmium, an effector in the synthesis of thionein.
作者信息
Bryan S E, Hidalgo H A, Koppa V, Smith H A
出版信息
Environ Health Perspect. 1979 Feb;28:281-5. doi: 10.1289/ehp.7928281.
Abstract
Cadmium can elicit the synthesis of thionein in liver cells independent of tissue-organ interactions. The metal diffuses across the plasma membrane and is partitioned between subcellular components in a time dependent manner such that thionein synthesis responds to levels of nonspecifically and specifically bound cytoplasmic metal. Cadmium appears to function at the transcriptional level, and the metal may act to increase the pool of specific m-RNA's.
摘要
镉可在不依赖组织 - 器官相互作用的情况下诱导肝细胞中硫蛋白的合成。这种金属穿过质膜扩散，并以时间依赖的方式在亚细胞组分之间分配，使得硫蛋白的合成对非特异性和特异性结合的细胞质金属水平作出反应。镉似乎在转录水平发挥作用，并且这种金属可能起到增加特定信使核糖核酸池的作用。
相似文献
1
Cadmium, an effector in the synthesis of thionein.镉，硫蛋白合成中的一种效应物。
Environ Health Perspect. 1979 Feb;28:281-5. doi: 10.1289/ehp.7928281.
2
Cadmium-thionein and the protection by cadmium against the nephrotoxicity of mercury.镉硫蛋白与镉对汞肾毒性的保护作用。
Chem Biol Interact. 1976 Aug;14(3-4):357-69. doi: 10.1016/0009-2797(76)90114-9.
3
Induction of cadmium-thionein in isolated rat liver cells.镉硫蛋白在离体大鼠肝细胞中的诱导作用。
Biochem J. 1978 Feb 15;170(2):219-225. doi: 10.1042/bj1700219.
4
Estimation of thionein synthesis in cultured cells by slab gel electrophoresis.通过平板凝胶电泳法估算培养细胞中硫蛋白的合成量。
Ind Health. 1982;20(2):101-8. doi: 10.2486/indhealth.20.101.
5
Long-term turnover of cadmium metallothionein in liver and kidney following a single low dose of cadmium in rats.大鼠单次低剂量镉染毒后肝脏和肾脏中镉金属硫蛋白的长期周转
Biochim Biophys Acta. 1981 Mar 5;673(2):177-83.
6
Degradation of cadmium-thionein in rat liver and kidney.大鼠肝脏和肾脏中镉硫蛋白的降解
J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):463-72.
7
Early cellular effects of circulating cadmium-thionein on kidney proximal tubules.循环镉硫蛋白对肾近端小管的早期细胞效应。
Environ Health Perspect. 1979 Feb;28:287-96. doi: 10.1289/ehp.7928287.
8
Cadmium inhibition of in vitro hepatic oxidative drug metabolism in the rat: comparison between ionic cadmium and cadmium-thionein.镉对大鼠体外肝脏氧化药物代谢的抑制作用：离子镉与镉硫蛋白的比较。
Res Commun Chem Pathol Pharmacol. 1982 Feb;35(2):349-52.
9
Cadmium-115 bound to nuclear and cytoplasmic proteins.镉-115与细胞核和细胞质蛋白结合。
Toxicol Appl Pharmacol. 1977 Nov;42(2):319-27. doi: 10.1016/0041-008x(77)90008-4.
10
Degradation of cadmium-thionein in rat liver and kidney.大鼠肝脏和肾脏中镉硫蛋白的降解
J Toxicol Environ Health. 1978 Sep-Nov;4(5-6):805-13. doi: 10.1080/15287397809529701.
引用本文的文献
1
The movement of zinc and copper from the fertilized egg into metallothionein-like proteins in developing chick hepatic tissue.锌和铜在鸡胚卵向发育中的鸡肝组织金属硫蛋白样蛋白中的转移。
Biol Trace Elem Res. 1983 Dec;5(6):503-15. doi: 10.1007/BF02988942.
2
Uptake and binding of cadmium and mercury to metallothionein in rat hepatocyte primary cultures.镉和汞在大鼠肝细胞原代培养物中对金属硫蛋白的摄取与结合
Biochem J. 1982 Nov 15;208(2):465-72. doi: 10.1042/bj2080465.
3
Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA.鸡金属硫蛋白的分子克隆。完整氨基酸序列的推导及利用克隆的cDNA对表达的分析。
Nucleic Acids Res. 1988 Jan 25;16(2):537-53. doi: 10.1093/nar/16.2.537.
本文引用的文献
1
Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex.金属硫蛋白：一种来自马肾皮质的含镉和锌的蛋白质。
J Biol Chem. 1960 Dec;235:3460-5.
2
Cd(2+), Mn(2+) and Zn(2+) induced synthesis of nuclear RNA in the livers of normal and adrenalectomized rats.镉离子（Cd²⁺）、锰离子（Mn²⁺）和锌离子（Zn²⁺）诱导正常大鼠和肾上腺切除大鼠肝脏中核RNA的合成。
FEBS Lett. 1970 Oct 5;10(3):169-174. doi: 10.1016/0014-5793(70)80445-8.
3
Isolation and some properties of human metallothionein.人金属硫蛋白的分离及某些特性
Biochemistry. 1966 May;5(5):1768-77. doi: 10.1021/bi00869a046.
4
Binding of mercury in the rat kidney by metallothionein.金属硫蛋白对大鼠肾脏中汞的结合作用。
Toxicol Appl Pharmacol. 1970 May;16(3):754-63. doi: 10.1016/0041-008x(70)90081-5.
5
Separation of two forms of rabbit metallothionein by isoelectric focusing.通过等电聚焦分离兔金属硫蛋白的两种形式。
Biochem J. 1972 Feb;126(3):491-8. doi: 10.1042/bj1260491.
6
Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.马肝脏和肾脏中的金属硫蛋白。纯化、分子量、氨基酸组成及金属含量。
J Biol Chem. 1974 Jun 10;249(11):3537-42.
7
Cadmium-induced synthesis of hepatic metallothionein in chicken and rats.镉诱导鸡和大鼠肝脏金属硫蛋白的合成。
FEBS Lett. 1973 May 15;32(1):171-4. doi: 10.1016/0014-5793(73)80764-1.
8
Purification and some properties of Cd-binding protein from rat liver.大鼠肝脏镉结合蛋白的纯化及某些性质
Arch Biochem Biophys. 1972 Dec;153(2):755-62. doi: 10.1016/0003-9861(72)90395-5.
9
Cadmium and zinc binding in mammalian liver and kidneys.镉和锌在哺乳动物肝脏和肾脏中的结合
Arch Environ Health. 1972 Jun;24(6):419-25. doi: 10.1080/00039896.1972.10666118.
10
Control of cadmium binding protein synthesis in rat liver.大鼠肝脏中镉结合蛋白合成的调控
Environ Physiol Biochem. 1974;4(1):24-30.
Zotero 插件