Polak J M, Pearse A G, Grimelius L, Bloom S R
Lancet. 1975 May 31;1(7918):1220-2. doi: 10.1016/s0140-6736(75)92198-4.
The normal pancreatic D cell has been well recognised since 1931, but its secretory product has not been identified with certainty. Combined immunocytochemical methods, and histological methods for endocrine granules, have demonstrated that it contains a product with G.H.-R.I.H.-like immunoreactivity. G.H.-R.I.H. has also been localised in the upper gastrointestinal tract, tentatively in the morphologically similar D cell of the Wiesbaden classification. The potent actions of this peptide on pancreatic and gastrointestinal function suggest that it may play an important role in digestive physiology.
自1931年以来，正常胰腺D细胞已得到充分认识，但其分泌产物尚未得到确切鉴定。联合免疫细胞化学方法以及内分泌颗粒的组织学方法已证明，它含有一种具有生长激素释放抑制因子样免疫反应性的产物。生长激素释放抑制因子也已定位在上消化道，初步定位于威斯巴登分类中形态相似的D细胞。这种肽对胰腺和胃肠功能的强大作用表明，它可能在消化生理学中发挥重要作用。
