Polak J M, Bloom S R, Rayford P L, Pearse A G, Buchan A M, Thompson J C
Lancet. 1975 Nov 22;2(7943):1016-8. doi: 10.1016/s0140-6736(75)90297-4.
Cholecystokinin (C.C.K.)-producing cells were identified in the mucosa of the upper small intestine in man and other mammals by immunocytochemical techniques and electron microscopy on semi-thin and serial thin sections. Ultrastructural studies suggested that the C.C.K.-producing cells resemble I cells of the modified Wiesbaden classification. The combination of these techniques provides a simple and reliable method of identifying C.C.K. cells in human biopsy material and will be useful in the investigation and diagnosis of gut endocrine dysfunctions.
通过免疫细胞化学技术以及对半薄切片和连续超薄切片进行电子显微镜观察，在人类和其他哺乳动物的上段小肠黏膜中鉴定出了产生胆囊收缩素（C.C.K.）的细胞。超微结构研究表明，产生C.C.K.的细胞类似于改良的威斯巴登分类中的I细胞。这些技术的结合提供了一种简单可靠的方法，用于在人类活检材料中识别C.C.K.细胞，将有助于肠道内分泌功能障碍的研究和诊断。
