Boisselle A, Tremblay R R
Fertil Steril. 1979 Sep;32(3):276-9. doi: 10.1016/s0015-0282(16)44232-9.
Spironolactone, an aldosterone antagonist currently used in the treatment of hypertension, has numerous antiandrogenic side effects. Decreased production rates of testosterone in intact (N = 10) and hirsute (N = 6) women, respectively, were noted after short (7 days) or long-term (6 months) administration of the drug, 25 mg twice daily. A 50% diminution in the urinary 17-ketosteroid excretion was also observed after 6 months of therapy. Assessment of the treatment was done by the patients: a reduction in hair growth rate was initially observed after 3 to 4 months, followed by the appearance of a more downy type of new growth and a decrease in diameter of the hair shaft. It is concluded that this beneficial effect is obtained by a decrease in the testosterone production rate and probably through competitive inhibition of spironolactone and/or canrenone with the androgen receptor in human hair follicles.
螺内酯是一种目前用于治疗高血压的醛固酮拮抗剂，有许多抗雄激素副作用。在完整女性（N = 10）和多毛女性（N = 6）中，分别在短期（7天）或长期（6个月）每日两次服用25毫克该药物后，观察到睾酮生成率降低。治疗6个月后，尿17 - 酮类固醇排泄量也减少了50%。患者对治疗进行了评估：最初在3至4个月后观察到毛发生长速度降低，随后出现更柔软的新生毛发类型，毛干直径减小。得出的结论是，这种有益效果是通过降低睾酮生成率以及可能通过螺内酯和/或坎利酮与人毛囊中的雄激素受体竞争性抑制而获得的。
