Saksena S K, Lau I F, Chang M C
Prostaglandins Med. 1978 Aug;1(2):107-15. doi: 10.1016/0161-4630(78)90036-8.
Silastic-PVP-PGF2alpha tubes significantly reduced the sperm population in the epididymis and vas-deferens of male rats 14 days after their insertion into the scrotal sacs. A reduction in testis and epididymal weights was also evident. The reduction of sperm population was accompanied by a normal sexual drive and circulating testosterone level and partial sterility. The reduction in sperm population and induction of partial sterility was detected at least 7 days after the total release of prostaglandin F2alpha from the Silastic-PVP tubes. The results suggest that the changes in the reproductive parameters might be a consequence of endocrinological and functional disturbances induced by PGF2alpha and that PGs can be used to induce temporary sterility in the male.
硅橡胶-聚乙烯吡咯烷酮-前列腺素F2α管在植入雄性大鼠阴囊囊14天后，显著减少了附睾和输精管中的精子数量。睾丸和附睾重量的减轻也很明显。精子数量的减少伴随着正常的性欲和循环睾酮水平以及部分不育。在前列腺素F2α从硅橡胶-聚乙烯吡咯烷酮管中完全释放至少7天后，检测到精子数量减少和部分不育的诱导。结果表明，生殖参数的变化可能是前列腺素F2α引起的内分泌和功能紊乱的结果，并且前列腺素可用于诱导雄性暂时不育。
