小鼠免疫反应中的品系差异。II. 受辐照成年宿主中新生细胞的反应。
Strain differences in the immune response of mice. II. Responses by neonatal cells in irradiated adult hosts.
作者信息
Playfair J H
出版信息
Immunology. 1968 Dec;15(6):815-26.
Lethally irradiated NZB and C57BL mice were injected with syngeneic thymus and marrow, or thymus and liver cells, and immunized with sheep red blood cells (SRBC). As in intact neonatal mice, NZB plaque-forming cell (PFC) responses were significantly higher than C57BL. Irradiated (NZB×C57BL)F and (NZB×BALB/c)F hybrid mice were given mixtures of parental and syngeneic cells, and it was shown that the high NZB response to SRBC was characteristic of the newborn liver rather than of the thymus. NZB liver gave rise to more PFC against SRBC than BALB/c liver, but not more against chicken RBC. It is argued that liver cells contain genetic information regarding antibody specificity. C57BL cells grew poorly in F hosts, but the low SRBC response appeared to be characteristic of both liver and thymus. The nomenclature of the participating cells, and their role in the development of immunological responsiveness, are discussed.
对受到致死剂量照射的新西兰黑鼠（NZB）和C57BL小鼠注射同基因胸腺细胞和骨髓细胞，或胸腺细胞和肝细胞，并用绵羊红细胞（SRBC）进行免疫。与完整的新生小鼠一样，NZB的空斑形成细胞（PFC）反应显著高于C57BL。给受照射的（NZB×C57BL）F1和（NZB×BALB/c）F1杂种小鼠注射亲代细胞和同基因细胞的混合物，结果表明，NZB对SRBC的高反应性是新生肝脏而非胸腺的特征。NZB肝脏产生的针对SRBC的PFC比BALB/c肝脏多，但针对鸡红细胞的PFC并不更多。有人认为肝细胞含有关于抗体特异性的遗传信息。C57BL细胞在F1宿主中生长不良，但对SRBC的低反应似乎是肝脏和胸腺的共同特征。文中讨论了参与细胞的命名及其在免疫反应性发育中的作用。
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