Playfair J H, Marshall-Clarke S
Immunology. 1973 Mar;24(3):579-88.
The response of bone marrow (B) cells to sheep red blood cells (SRBC) was measured in the presence of thymus-derived (T) cells that had been stimulated by SRBC or RBC from other species. It was found that other RBC, notably pig and rabbit, were much more effective in stimulating T cells for a cooperative response to SRBC than would have been predicted from the very slight cross-reaction between these RBC and SRBC at the antibody level. It is concluded that recognition of antigens at the T-cell level is different, and in this case less specific, than at the level of the B cells.
在存在经绵羊红细胞(SRBC)或其他物种红细胞刺激的胸腺来源(T)细胞的情况下,测量了骨髓(B)细胞对绵羊红细胞(SRBC)的反应。结果发现,其他红细胞,尤其是猪和兔的红细胞,在刺激T细胞以协同应对SRBC方面比根据这些红细胞与SRBC在抗体水平上非常轻微的交叉反应所预测的更为有效。得出的结论是,T细胞水平对抗原的识别与B细胞水平不同,在这种情况下特异性更低。