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大肠杆菌中β-半乳糖苷酶瞬时抑制的分子基础。

Molecular basis of transient repression of beta-galactosidase in Escherichia coli.

作者信息

Tyler B, Magasanik B

出版信息

J Bacteriol. 1969 Feb;97(2):550-6. doi: 10.1128/jb.97.2.550-556.1969.

DOI:10.1128/jb.97.2.550-556.1969
PMID:4886283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249726/
Abstract

The molecular basis of transient repression of beta-galactosidase by glucose was examined. This repression acted only at the level of transcription. Apparently, it was not mediated by the I-gene product. Analysis of single cells in a culture subjected to transient repression showed that essentially all cells initially experienced repression and later became gradually resistant to repression.

摘要

研究了葡萄糖对β-半乳糖苷酶瞬时抑制的分子基础。这种抑制仅作用于转录水平。显然，它不是由I基因产物介导的。对处于瞬时抑制状态的培养物中的单细胞进行分析表明，基本上所有细胞最初都经历了抑制，随后逐渐对抑制产生抗性。

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1
Molecular basis of transient repression of beta-galactosidase in Escherichia coli.大肠杆菌中β-半乳糖苷酶瞬时抑制的分子基础。
J Bacteriol. 1969 Feb;97(2):550-6. doi: 10.1128/jb.97.2.550-556.1969.
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本文引用的文献

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Isolation of the lac repressor.乳糖阻遏蛋白的分离
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1891-8. doi: 10.1073/pnas.56.6.1891.
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THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI.诱导物和分解代谢物阻遏物在大肠杆菌β-半乳糖苷酶合成中的作用
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KINETICS OF INDUCED ENZYME SYNTHESIS. DETERMINATION OF THE MEAN LIFE OF GALACTOSIDASE-SPECIFIC MESSENGER RNA.诱导酶合成动力学。半乳糖苷酶特异性信使核糖核酸平均寿命的测定。
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THE ROLE OF RNA IN REPRESSION OF ENZYME SYNTHESIS.RNA在酶合成抑制中的作用。
Proc Natl Acad Sci U S A. 1963 Dec;50(6):1059-66. doi: 10.1073/pnas.50.6.1059.
5
SPECIFIC METABOLIC REPRESSION OF THREE INDUCED ENZYMES IN ESCHERICHIA COLI.大肠杆菌中三种诱导酶的特异性代谢抑制
Biochem J. 1963 Nov;89(2):391-8. doi: 10.1042/bj0890391.
6
Measurement of activity of single molecules of beta-D-galactosidase.β-D-半乳糖苷酶单分子活性的测量
Proc Natl Acad Sci U S A. 1961 Dec 15;47(12):1981-91. doi: 10.1073/pnas.47.12.1981.
7
Fluorogenic substrates for beta-D-galactosidases and phosphatases derived from flurescein (3,6-dihydroxyfluoran) and its monomethylether.源自荧光素（3,6-二羟基荧光黄）及其单甲醚的β-D-半乳糖苷酶和磷酸酶的荧光底物。
Proc Natl Acad Sci U S A. 1963 Jul;50(1):1-6. doi: 10.1073/pnas.50.1.1.
8
Kinetic studies of beta-galactosidase induction.β-半乳糖苷酶诱导的动力学研究。
Biophys J. 1961 Nov;1(8):639-47. doi: 10.1016/s0006-3495(61)86913-0.
9
Changes during the division cycle in bacterial cell wall synthesis, volume, and ability to concentrate free amino acids.细菌细胞壁合成、体积以及游离氨基酸浓缩能力在分裂周期中的变化。
Biochim Biophys Acta. 1960 Oct 7;43:520-30. doi: 10.1016/0006-3002(60)90474-1.
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Genetic regulatory mechanisms in the synthesis of proteins.蛋白质合成中的遗传调控机制。
J Mol Biol. 1961 Jun;3:318-56. doi: 10.1016/s0022-2836(61)80072-7.