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1
Mutations of Chinese hamster somatic cells from 2-deoxygalactose sensitivity to resistance.中国仓鼠体细胞从对2-脱氧半乳糖敏感突变为抗性。
Genetics. 1979 Jun;92(2):563-72. doi: 10.1093/genetics/92.2.563.
2
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Immunological and genetic characterization of 2-deoxygalactose-resistant, galactokinase-deficient mutants of Chinese hamster cells: evidence for structural mutations at the galK locus.中国仓鼠细胞中对2-脱氧半乳糖具有抗性、半乳糖激酶缺陷型突变体的免疫学和遗传学特征：galK基因座存在结构突变的证据
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4
Galactokinase mutants of Chinese hamster somatic cells resistant to 2-deoxygalactose.对2-脱氧半乳糖具有抗性的中国仓鼠体细胞的半乳糖激酶突变体
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Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A.中国仓鼠V79细胞突变体V-H4中HPRT基因自发发生的突变谱，该突变体与范可尼贫血A组同源。
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A deterministic approach for the estimation of mutation rates in cultured mammalian cells.一种用于估计培养的哺乳动物细胞中突变率的确定性方法。
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引用本文的文献

1
Immunological and genetic characterization of 2-deoxygalactose-resistant, galactokinase-deficient mutants of Chinese hamster cells: evidence for structural mutations at the galK locus.中国仓鼠细胞中对2-脱氧半乳糖具有抗性、半乳糖激酶缺陷型突变体的免疫学和遗传学特征：galK基因座存在结构突变的证据
Mol Cell Biol. 1984 Nov;4(11):2413-9. doi: 10.1128/mcb.4.11.2413-2419.1984.

本文引用的文献

1
Mutations of Bacteria from Virus Sensitivity to Virus Resistance.细菌从对病毒敏感到对病毒抗性的突变。
Genetics. 1943 Nov;28(6):491-511. doi: 10.1093/genetics/28.6.491.
2
Observations on the chromosomes of Chinese hamster cells in tissue culture.对组织培养中的中国仓鼠细胞染色体的观察。
J Natl Cancer Inst. 1958 Aug;21(2):393-425.
3
Mammalian cell genetics. I. Selection and characterization of mutations auxotrophic for L-glutamine or resistant to 8-azaguanine in Chinese hamster cells in vitro.哺乳动物细胞遗传学。I. 体外培养的中国仓鼠细胞中对L-谷氨酰胺营养缺陷或对8-氮杂鸟嘌呤有抗性的突变体的筛选与鉴定。
Genetics. 1969 Jun;62(2):359-77. doi: 10.1093/genetics/62.2.359.
4
Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase.缺乏腺嘌呤磷酸核糖转移酶的中国仓鼠培养细胞突变体。
Cell. 1974 May;2(1):43-54. doi: 10.1016/0092-8674(74)90007-5.
5
Galactokinase mutants of Chinese hamster somatic cells resistant to 2-deoxygalactose.对2-脱氧半乳糖具有抗性的中国仓鼠体细胞的半乳糖激酶突变体
Genetics. 1976 May;83(1):137-147. doi: 10.1093/genetics/83.1.137.
6
The isolation and preliminary characterization of somatic cell mutants resistant to the protein synthesis inhibitor-emetine.对蛋白质合成抑制剂依米丁具有抗性的体细胞突变体的分离与初步鉴定。
Cell. 1976 Oct;9(2):213-9. doi: 10.1016/0092-8674(76)90112-4.
7
Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis.通过分离分析证明CHO细胞中Emtr基因座存在功能性半合子状态。
Cell. 1978 Aug;14(4):1007-13. doi: 10.1016/0092-8674(78)90354-9.
8
Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.通过染色体介导的基因转移共转移胸苷激酶和半乳糖激酶基因。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):914-8. doi: 10.1073/pnas.75.2.914.

中国仓鼠体细胞从对2-脱氧半乳糖敏感突变为抗性。

Mutations of Chinese hamster somatic cells from 2-deoxygalactose sensitivity to resistance.

作者信息

Claverie J M, de Souza A C, Thirion J P

出版信息

Genetics. 1979 Jun;92(2):563-72. doi: 10.1093/genetics/92.2.563.

DOI:10.1093/genetics/92.2.563
PMID:488705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213976/
Abstract

In Chinese hamster somatic cells, the spontaneous change of phenotype from 2-deoxygalactose sensitivity to resistance was studied using fluctuation test experiments à la Luria and Delbrück (1943) for four Chinese hamster cell strains derived from V79. The results are consistent with true mutational events. The mutation rates are in the range of 1 to 3.5 X 10(-5) per cell per generation. The relationship between the 2-deoxyglactose resistance and the galactokinase markers is discussed.

摘要

在中国仓鼠体细胞中，使用类似卢里亚和德尔布吕克（1943年）的波动试验，对源自V79的四种中国仓鼠细胞株进行了从对2-脱氧半乳糖敏感到抗性的表型自发变化研究。结果与真正的突变事件一致。突变率在每代每个细胞1至3.5×10⁻⁵的范围内。讨论了2-脱氧半乳糖抗性与半乳糖激酶标记之间的关系。