鼠伤寒沙门氏菌中影响核糖体合成的冷敏感突变。
Cold-sensitive mutations in Salmonella typhimurium which affect ribosome synthesis.
作者信息
Tai P C, Kessler D P, Ingraham J
出版信息
J Bacteriol. 1969 Mar;97(3):1298-304. doi: 10.1128/jb.97.3.1298-1304.1969.
Abstract
A number of mutations (45) expressed as cold-sensitive conditional lethal pheno-types were screened by transduction for their linkage to the streptomycin-resistance locus; 7 showed such linkage. Of these, two were studied in greater detail. The sedimentation profiles of ribosomes from cultures grown at low temperature differed from wild type and from one another. Both mutants lost ribonucleic acid control at low temperature. It is suggested that a high proportion of mutants expressing a cold-sensitive phenotype harbor mutations in genes affecting ribosome synthesis or regulation.
摘要
通过转导筛选了许多表现为冷敏感条件致死表型的突变体（45个），以确定它们与链霉素抗性位点的连锁关系；其中7个显示出这种连锁关系。对其中两个进行了更详细的研究。在低温下生长的培养物中核糖体的沉降图谱与野生型不同，且彼此也不同。两个突变体在低温下都失去了核糖核酸控制。有人提出，高比例表现出冷敏感表型的突变体在影响核糖体合成或调控的基因中存在突变。
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