24,25-二羟胆钙化醇是人机体中的一种钙调节激素吗？
Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?
作者信息
Kanis J A, Cundy T, Bartlett M, Smith R, Heynen G, Warner G T, Russell R G
出版信息
Br Med J. 1978 May 27;1(6124):1382-6. doi: 10.1136/bmj.1.6124.1382.
Abstract
Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent.
摘要
小剂量（每日1 - 10微克）的24,25 - 二羟胆钙化醇（24,25-(OH)₂D₃），一种功能不明的维生素D肾脏代谢产物，可增加正常人以及患有各种疾病或矿物质代谢紊乱患者（包括无肾受试者）的肠道钙吸收。在研究的6名患者中，有5名患者的钙平衡增加，但与1,25 - 二羟胆钙化醇不同，24,25-(OH)₂D₃并未增加血浆或尿钙浓度。这些结果表明，24,25-(OH)₂D₃可能是人体骨骼代谢的重要调节剂，具有作为治疗剂的潜在价值。
相似文献
1
Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?24,25-二羟胆钙化醇是人机体中的一种钙调节激素吗？
Br Med J. 1978 May 27;1(6124):1382-6. doi: 10.1136/bmj.1.6124.1382.
2
Effect of oral 1,25 dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis.口服1,25-二羟胆钙化醇对原发性胆汁性肝硬化钙和磷吸收不良的影响。
Gut. 1979 Jul;20(7):616-9. doi: 10.1136/gut.20.7.616.
3
Intestinal phosphate absorption in normal and uremic man: effects of 1,25(OH)2-vitamin D3 and 1alpha(OH)-vitamin D3.
Adv Exp Med Biol. 1977;81:549-57. doi: 10.1007/978-1-4613-4217-5_53.
4
Comparison of effects of 1 alpha-hydroxy-vitamin D3 and 1,25-dihydroxy-vitamin D3 in man.1α-羟基维生素D3与1,25-二羟基维生素D3对人体作用的比较。
J Clin Invest. 1976 Jun;57(6):1540-7. doi: 10.1172/JCI108424.
5
Effect of 25-hydroxy-vitamin D3 on intestinal absorption of calcium in normal man and patients with renal failure.25-羟维生素D3对正常人及肾衰竭患者肠道钙吸收的影响。
Metabolism. 1978 Jun;27(6):745-53. doi: 10.1016/0026-0495(78)90013-6.
6
The effect of 1,25-dihydroxycholecalciferol on renal tubular reabsorption of phosphate, intestinal absorption of calcium and bone histology in hypophosphataemic renal tubular rickets.
Clin Sci Mol Med. 1975 Mar;48(3):177-86. doi: 10.1042/cs0480177.
7
Physiological and pharmacological aspects of 24,25-dihydroxycholecalciferol in man.人体内24,25-二羟胆钙化醇的生理和药理学特性
Adv Exp Med Biol. 1978;103:487-503. doi: 10.1007/978-1-4684-7758-0_49.
8
Effect of 1alpha-hydroxycholecalciferol, 1,25-dihydroxycholecalciferol, 3 deoxy-1alpha-hydroxycholecalciferol, 24R, 25-dihydroxycholecalciferol and successful renal transplantation on calcium absorption in haemodialysis patients.1α-羟基胆钙化醇、1,25-二羟基胆钙化醇、3-脱氧-1α-羟基胆钙化醇、24R,25-二羟基胆钙化醇及肾移植成功对血液透析患者钙吸收的影响
Nephron. 1978;20(4):203-11. doi: 10.1159/000181223.
9
Action of 1,25-dihydroxyvitamin D3 and a diphosphonate on calcium metabolism in rats.1,25 - 二羟维生素D3和一种双膦酸盐对大鼠钙代谢的作用
Am J Physiol. 1975 Aug;229(2):402-8. doi: 10.1152/ajplegacy.1975.229.2.402.
10
1,25 dihydroxycholecalciferol effects in chronic dialysis. A double-blind controlled study.1,25-二羟胆钙化醇在慢性透析中的作用。一项双盲对照研究。
Ann Intern Med. 1978 Jun;88(6):774-80. doi: 10.7326/0003-4819-88-6-774.
引用本文的文献
1
The Influence of Solar-Simulated UV Radiation on Circulating 25(OH)D3, 24,25(OH)D3 and Their Ratio in Younger and Older Adults.模拟太阳紫外线辐射对年轻人和老年人循环中25(OH)D3、24,25(OH)D3及其比值的影响。
Nutrients. 2025 Jun 18;17(12):2039. doi: 10.3390/nu17122039.
2
Is 24,25(OH)D level really high in dialysis patients with high FGF23 levels?透析患者 FGF23 水平高时 24,25(OH)D 水平真的高吗？
Int Urol Nephrol. 2012 Aug;44(4):1135-44. doi: 10.1007/s11255-012-0157-5. Epub 2012 Mar 31.
3
25-Hydroxycholecalciferol serum levels in breast-fed infants.母乳喂养婴儿的血清25-羟胆钙化醇水平
Arch Dis Child. 1980 Sep;55(9):691-5. doi: 10.1136/adc.55.9.691.
4
[Renal osteodystrophy in children. Therapy with 1,25-dihydroxy-cholechalciferol (author's transl)].儿童肾性骨营养不良。1,25 - 二羟胆钙化醇治疗（作者译）
Klin Wochenschr. 1980 May 16;58(10):511-9. doi: 10.1007/BF01477068.
5
Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration.不同类固醇给药治疗方案下儿童肾病患者的血清25（OH）D和24,25（OH）₂水平
Eur J Pediatr. 1982 Mar;138(2):162-5. doi: 10.1007/BF00441145.
6
Treatment of renal osteodystrophy with 1,25-dihydroxycholecalciferol.用1,25 - 二羟胆钙化醇治疗肾性骨营养不良。
Can Med Assoc J. 1981 Mar 1;124(5):577-83.
7
Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro.维生素D代谢产物及类似物对体外骨胶原合成的影响。
Calcif Tissue Int. 1982 Jan;34(1):103-10. doi: 10.1007/BF02411216.
8
Relative effectiveness of vitamin D metabolites in increasing bone mineral solubility.维生素D代谢物在增加骨矿物质溶解度方面的相对有效性。
Calcif Tissue Int. 1981;33(2):159-65. doi: 10.1007/BF02409429.
9
Effects of 1 alpha-hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on bone remodeling.1α-羟基维生素D3和24R,25-二羟基维生素D3对骨重塑的影响。
Calcif Tissue Int. 1980;31(3):209-13. doi: 10.1007/BF02407183.
10
A monolog on analogs: in vitro effects of vitamin D metabolites and consideration of the mineralization question.维生素D类似物的独白：维生素D代谢产物的体外效应及矿化问题的思考
Calcif Tissue Int. 1981;33(1):1-4. doi: 10.1007/BF02409404.
本文引用的文献
1
A whole-body counter for clinical measurements utilizing the 'shadow shield' technique.
Phys Med Biol. 1966 Jan;11(1):83-94. doi: 10.1088/0031-9155/11/1/307.
2
Use of cuprous thiocyanate as a short-term continuous marker for faeces.使用硫氰酸亚铜作为粪便的短期连续标记物。
Gut. 1969 May;10(5):408-12. doi: 10.1136/gut.10.5.408.
3
Role of vitamin D metabolites in phosphate transport of rat intestine.维生素D代谢产物在大鼠肠道磷转运中的作用。
J Nutr. 1974 Aug;104(8):1056-60. doi: 10.1093/jn/104.8.1056.
4
The biological activity and metabolism of 24,25-dihydroxyvitamin D 3 .24,25-二羟维生素D3的生物学活性与代谢
J Biol Chem. 1973 Jun 25;248(12):4174-80.
5
The effects of vitamin D analogues on bone resorption.维生素D类似物对骨吸收的影响。
Calcif Tissue Res. 1974;15(4):333-9. doi: 10.1007/BF02059069.
6
Inhibition of vitamin D metabolism by ethane-1-hydroxyl-1, 1-diphosphonate.
Arch Biochem Biophys. 1974 Oct;164(2):655-62. doi: 10.1016/0003-9861(74)90077-0.
7
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.1,25-二羟胆钙化醇：组织培养中骨吸收的强效刺激剂。
Science. 1972 Feb 18;175(4023):768-9. doi: 10.1126/science.175.4023.768.
8
Failure of formation of 1,25-dihydroxycholecalciferol in chronic renal insufficiency.慢性肾功能不全时1,25 - 二羟胆钙化醇生成障碍。
Lancet. 1973 Mar 24;1(7804):626-8. doi: 10.1016/s0140-6736(73)92197-1.
9
Metabolism and biologica.代谢与生物学。
不过你提供的原文“Metabolism and biologica.”有误，正确的应该是“Metabolism and biology” 。
J Biol Chem. 1976 Jan 25;251(2):397-402.
10
Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance.24,25-二羟基维生素D3中24-羟基的立体化学构型的测定及其生物学重要性。
Arch Biochem Biophys. 1975 Oct;170(2):620-6. doi: 10.1016/0003-9861(75)90157-5.
Zotero 插件