24,25-二羟胆钙化醇是人机体中的一种钙调节激素吗？
Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?
作者信息
Kanis J A, Cundy T, Bartlett M, Smith R, Heynen G, Warner G T, Russell R G
出版信息
Br Med J. 1978 May 27;1(6124):1382-6. doi: 10.1136/bmj.1.6124.1382.
Abstract
Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent.
摘要
小剂量（每日1 - 10微克）的24,25 - 二羟胆钙化醇（24,25-(OH)₂D₃），一种功能不明的维生素D肾脏代谢产物，可增加正常人以及患有各种疾病或矿物质代谢紊乱患者（包括无肾受试者）的肠道钙吸收。在研究的6名患者中，有5名患者的钙平衡增加，但与1,25 - 二羟胆钙化醇不同，24,25-(OH)₂D₃并未增加血浆或尿钙浓度。这些结果表明，24,25-(OH)₂D₃可能是人体骨骼代谢的重要调节剂，具有作为治疗剂的潜在价值。
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