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溴甲贝那替秦治疗老年人夜尿症的临床试验

Clinical trial of emepronium bromide in nocturnal frequency of old age.

作者信息

Brocklehurst J C, Dillane J B, Fry J, Armitage P

出版信息

Br Med J. 1969 Apr 26;2(5651):216-8. doi: 10.1136/bmj.2.5651.216.

DOI:10.1136/bmj.2.5651.216
PMID:4888873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1983090/
Abstract

A double-blind cross-over trial of emepronium bromide (Cetiprin) in nocturnal frequency of micturition in a group of elderly women living in their homes showed that the drug was superior to placebo in diminishing urinary frequency, though not every person benefited. It is suggested that the drug may alter the established habit of rising at night to pass urine. Side-effects were negligible.

摘要

对一组居家老年女性进行的溴美喷酯(西替普林)治疗夜间尿频的双盲交叉试验表明,该药物在减少尿频方面优于安慰剂,尽管并非每个人都从中受益。有人认为该药物可能会改变夜间起床排尿的既定习惯。副作用可忽略不计。

相似文献

1
Clinical trial of emepronium bromide in nocturnal frequency of old age.溴甲贝那替秦治疗老年人夜尿症的临床试验
Br Med J. 1969 Apr 26;2(5651):216-8. doi: 10.1136/bmj.2.5651.216.
2
Treatment of urgency by instillation of emepronium bromide in the urinary bladder.通过向膀胱内滴注溴化依美溴铵治疗尿急。
Scand J Urol Nephrol. 1978;12(3):215-8. doi: 10.3109/00365597809179719.
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[Cetiprin in increased night urination frequency of older patients].[西替普林治疗老年患者夜间尿频增加]
Ther Umsch. 1977 Jul;34(7):494-7.
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Effect of emepronium bromide (Cetiprin) on symptoms and urinary bladder function after transurethral resection of the prostate. A double-blind randomized trial.溴化依米普明(西替普明)对经尿道前列腺切除术后症状及膀胱功能的影响。一项双盲随机试验。
Urol Int. 1984;39(5):318-20. doi: 10.1159/000281002.
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Urinary incontinence in old age. A controlled clinical trial of emepronium bromide.老年尿失禁。溴美喷酯的对照临床试验。
Br J Urol. 1982 Jun;54(3):249-51. doi: 10.1111/j.1464-410x.1982.tb06968.x.
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[Treatment of nocturnal enuresis with emepronium bromide (Cetiprin). A controlled clinical trial].[用溴美喷酯(西替普林)治疗夜间遗尿症。一项对照临床试验]
Ugeskr Laeger. 1982 Jul 26;144(30):2224-6.
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Emepronium bromide in the management of nightly urinary frequency and urinary incontinence.
Practitioner. 1970 May;204(223):705-10.
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A comparison between the combination emepronium bromide/flavoxate and emepronium bromide in the treatment of detrusor instability.溴化依米普明/黄酮哌酯联合用药与溴化依米普明治疗逼尿肌不稳定的比较。
Urol Int. 1983;38(3):191-2. doi: 10.1159/000280889.
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The effect of intravesically administered Cetiprin on bladder spasms after transurethral resection of the prostate. A double-blind randomized study.膀胱内给予西替普林对经尿道前列腺切除术后膀胱痉挛的影响。一项双盲随机研究。
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A trial of emepronium bromide for the treatment of urinary incontinence in the elderly mentally ill.
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引用本文的文献

1
Clinical observations with Cetiprin (emepronium bromide).
Int Urol Nephrol. 1981;13(2):153-5. doi: 10.1007/BF02082058.
2
Status inconsistency in an "artificial practice".“人为实践”中的地位不一致。
J R Coll Gen Pract. 1969 Aug;18(85):86-90.
3
Urinary incontinence in old age.老年尿失禁
Br Med J. 1969 Jun 28;2(5660):777-8.
4
Continence and incontinence. A clinical study of the dynamics of voiding and of the sphincter mechanism.尿失禁与尿失禁。排尿动力学及括约肌机制的临床研究。
Ann R Coll Surg Engl. 1971 Jul;49(1):18-35.
5
Mode of action and relative value of imipramine and similar drugs in the treatment of nocturnal enuresis.丙咪嗪及类似药物治疗夜间遗尿症的作用方式及相对价值
Eur J Clin Pharmacol. 1974;7(3):187-94. doi: 10.1007/BF00560380.

本文引用的文献

1
Biological fate of C14-labelled ethyl (3,3-diphenyl-l-methyl-propyl) dimethylammoniumbromide Cetiprin, a monoquaternary ammonium compound.
Acta Pharmacol Toxicol (Copenh). 1961;18:183-90. doi: 10.1111/j.1600-0773.1961.tb00330.x.
2
A study of cetiprin as a urologic drug.西替普林作为一种泌尿科药物的研究。
Urol Int. 1957;4(5):293-305. doi: 10.1159/000277270.
3
Studies of the female bladder in old age. I. Cystometrograms in non-incontinent women.老年女性膀胱研究。I. 无尿失禁女性的膀胱测压图
Gerontol Clin (Basel). 1966;8(5):285-305. doi: 10.1159/000244965.
4
The prevalence and symptomatology of urinary infection in an aged population.老年人群泌尿系统感染的患病率及症状学
Gerontol Clin (Basel). 1968;10(4):242-53. doi: 10.1159/000245189.
5
Studies of the female bladder in old age. IV. Drug effects in urinary incontinence.老年女性膀胱研究。IV. 药物对尿失禁的影响。
Gerontol Clin (Basel). 1967;9(3):182-91 contd.