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荧光密螺旋体抗体吸收(FTA-ABS)试验。发展、应用及现状。

The fluorescent treponemal antibody-absorption (FTA-ABS) test. Development, use and present status.

作者信息

Hunter E F, Norins L C, Falcone V H, Stout G W

出版信息

Bull World Health Organ. 1968;39(6):873-81.

Abstract

For testing problem sera, the fluorescent treponemal antibody-absorption test (FTA-ABS) is increasingly replacing other treponemal tests for syphilis (including the TPI test) in the USA. The authors review its development as a result of experience with other immunofluorescent techniques and discuss its advantages and disadvantages. Although it is a more sensitive indicator of past or present syphilitic infection than many other widely evaluated techniques, several aspects of the test are still not fully understood; in particular its specificity is not yet established and more information is needed on its reactivity in a variety of clinical diseases and in treponemal diseases other than syphilis. It is a relatively expensive technique in terms of technicians' time, reagents and equipment but there are grounds for hope that research now under way into automation of the procedure may improve the situation.

摘要

在美国,对于检测疑难血清,荧光密螺旋体抗体吸收试验(FTA - ABS)正逐渐取代其他梅毒密螺旋体检测方法(包括TPI试验)。作者根据其他免疫荧光技术的经验回顾了该试验的发展历程,并讨论了其优缺点。尽管与许多其他经过广泛评估的技术相比,它是过去或现在梅毒感染更敏感的指标,但该试验的几个方面仍未被完全理解;特别是其特异性尚未确定,还需要更多关于它在各种临床疾病以及除梅毒外的其他密螺旋体疾病中的反应性的信息。就技术人员的时间、试剂和设备而言,这是一项相对昂贵的技术,但有理由希望目前正在进行的该检测程序自动化研究可能会改善这种情况。

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