隐性致死基因：大肠杆菌中一类新的无义抑制基因。
Recessive lethals: a new class of nonsense suppressors in Escherichia coli.
作者信息
Soll L, Berg P
出版信息
Proc Natl Acad Sci U S A. 1969 Jun;63(2):392-9. doi: 10.1073/pnas.63.2.392.
Abstract
Two new nonsense suppressors in Escherichia coli were found in partial diploids carrying F'14 and were shown to be on the episome. These suppressors can exist only in cells which also contain the su(-) allele, i.e., su(+)/su(-) heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal. Su7, an amber suppressor, has an efficiency of 76 per cent and su8, an ochre suppressor, an efficiency of 4 per cent.
摘要
在携带F'14的部分二倍体大肠杆菌中发现了两种新的无义抑制基因，并证明它们存在于附加体上。这些抑制基因只能存在于同时含有su(-)等位基因的细胞中，即su(+)/su(-)杂合子。据推测，这些突变导致了一种必需细胞成分的改变，其完全缺失是致死的。琥珀型抑制基因Su7的抑制效率为76%，赭石型抑制基因su8的抑制效率为4%。
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