Kovach J S, Phang J M, Ference M, Goldberger R F
Proc Natl Acad Sci U S A. 1969 Jun;63(2):481-8. doi: 10.1073/pnas.63.2.481.
Recent studies on repression of the enzymes for histidine bio-synthesis in Salmonella typhimurium demonstrated that the kinetic pattern in which the enzymes become repressed is influenced by the state of the feedback-sensitive site of the first enzyme of the pathway (Kovach et al., J. Bacteriol., 97, 1283 (1969)). In the present study we demonstrate that under certain conditions alteration of the feedback-sensitive site of the first enzyme prevents repression of the histidine operon. We conclude that the first enzyme plays a previously unrecognized role in regulation of the histidine system.
最近对鼠伤寒沙门氏菌中组氨酸生物合成酶的阻遏作用的研究表明，酶被阻遏的动力学模式受该途径第一种酶的反馈敏感位点状态的影响（科瓦奇等人，《细菌学杂志》，97卷，1283页（1969年））。在本研究中，我们证明在某些条件下，第一种酶的反馈敏感位点发生改变会阻止组氨酸操纵子的阻遏。我们得出结论，第一种酶在组氨酸系统的调节中发挥了以前未被认识到的作用。
