组氨酸操纵子的阻遏：第一种酶对阻遏动力学的影响。
Repression of the histidine operon: effect of the first enzyme on the kinetics of repression.
作者信息
Kovach J S, Berberich M A, Venetianer P, Goldberger R F
出版信息
J Bacteriol. 1969 Mar;97(3):1283-90. doi: 10.1128/jb.97.3.1283-1290.1969.
Abstract
Kinetic studies on repression of the enzymes for histidine biosynthesis in Salmonella typhimurium showed that, upon addition of histidine to a derepressed culture, the enzymes became repressed in a temporal sequence which corresponds with the positional sequence of the genes in the histidine operon. This serial pattern of repression occurred under conditions in which the feedback site of the first enzyme for histidine biosynthesis is intact. When this site was rendered nonfunctional the pattern of repression was changed so that all of the enzymes became repressed concomitantly. These results suggest that the first enzyme for histidine biosynthesis plays a hitherto unrecognized role in control of the histidine system.
摘要
对鼠伤寒沙门氏菌中组氨酸生物合成酶的阻遏进行的动力学研究表明，在向去阻遏培养物中添加组氨酸后，这些酶会按时间顺序被阻遏，该时间顺序与组氨酸操纵子中基因的位置顺序相对应。这种连续的阻遏模式是在组氨酸生物合成的第一种酶的反馈位点完整的条件下发生的。当该位点失去功能时，阻遏模式发生改变，所有酶会同时被阻遏。这些结果表明，组氨酸生物合成的第一种酶在组氨酸系统的调控中发挥了迄今未被认识到的作用。
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本文引用的文献
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