鼠伤寒沙门氏菌组氨酸生物合成的首个酶以及组氨酰转移核糖核酸合成酶的阻遏控制
First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
作者信息
Coleman W G, Williams L S
出版信息
J Bacteriol. 1974 Oct;120(1):390-3. doi: 10.1128/jb.120.1.390-393.1974.
Abstract
The regulation of formation of histidyl-transfer ribonucleic acid (tRNA) synthetase was examined in strains of Salmonella typhimurium. When the first of the histidine-forming enzymes was wild type, the presence of 2-thiazolealanine in the growth medium prevented repression of histidyl-tRNA synthetase formation elicited by the addition of 1, 2, 4-triazole-3-alanine to these cultures. Conversely, thiazolealanine had no effect on repression of histidyl-tRNA synthetase formation by triazolealanine in hisG mutant strains. These data suggest a relationship between the control of histidyl-tRNA synthetase formation and the functional state of the histidine operon.
摘要
在鼠伤寒沙门氏菌菌株中研究了组氨酰 - 转移核糖核酸（tRNA）合成酶形成的调控。当第一个组氨酸形成酶为野生型时，生长培养基中2 - 噻唑丙氨酸的存在可阻止因向这些培养物中添加1,2,4 - 三唑 - 3 - 丙氨酸而引发的组氨酰 - tRNA合成酶形成的阻遏。相反，在hisG突变菌株中，噻唑丙氨酸对三唑丙氨酸对组氨酰 - tRNA合成酶形成的阻遏没有影响。这些数据表明组氨酰 - tRNA合成酶形成的控制与组氨酸操纵子的功能状态之间存在关联。
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